%0 Journal Article %1 Lohse1996 %A Lohse, M. J. %D 1996 %J Z Kardiol %K Animals Contraction/physiology Epinephrine/physiology Failure/*physiopathology GTP-Binding Heart Humans Myocardial Norepinephrine/physiology Proteins/physiology Signal Transduction/physiology Vasodilation/physiology beta-1/*physiology beta-2/*physiology Receptor Adrenergic %P 1-3 %T Mechanisms of the regulation of adrenergic beta-receptors %U http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=9082678 %V 85 Suppl 7 %X Adrenaline and noradrenaline exert their effects via specific adrenergic receptors. Of the nine known subtypes of these receptors, the beta 1-subtype mediates an increase in cardiac contractility, while the beta 2-subtype is responsible for vasodilatation. These receptors are not just simple signal transducers but components of a complex and highly regulated signalling machinery. A loss of sensitivity of this machinery may be induced by exogenous as well as endogenous stimuli (= desensitisation). Desensitisation of cardiac beta-adrenergic receptors may contribute to contractile dysfunction in chronic heart failure.

@article{Lohse1996, abstract = {Adrenaline and noradrenaline exert their effects via specific adrenergic receptors. Of the nine known subtypes of these receptors, the beta 1-subtype mediates an increase in cardiac contractility, while the beta 2-subtype is responsible for vasodilatation. These receptors are not just simple signal transducers but components of a complex and highly regulated signalling machinery. A loss of sensitivity of this machinery may be induced by exogenous as well as endogenous stimuli (= desensitisation). Desensitisation of cardiac beta-adrenergic receptors may contribute to contractile dysfunction in chronic heart failure.}, added-at = {2010-12-14T18:12:02.000+0100}, author = {Lohse, M. J.}, biburl = {https://www.bibsonomy.org/bibtex/27d6249900a80f4231be6a376c1727c3b/pharmawuerz}, endnotereftype = {Journal Article}, interhash = {a902eeb24ddb1f9df44edad2d13ae523}, intrahash = {7d6249900a80f4231be6a376c1727c3b}, issn = {0300-5860 (Print) 0300-5860 (Linking)}, journal = {Z Kardiol}, keywords = {Animals Contraction/physiology Epinephrine/physiology Failure/*physiopathology GTP-Binding Heart Humans Myocardial Norepinephrine/physiology Proteins/physiology Signal Transduction/physiology Vasodilation/physiology beta-1/*physiology beta-2/*physiology Receptor Adrenergic}, note = {Lohse, M J English Abstract Review Germany Zeitschrift fur Kardiologie Z Kardiol. 1996;85 Suppl 7:1-3.}, pages = {1-3}, shorttitle = {[Mechanisms of the regulation of adrenergic beta-receptors]}, timestamp = {2010-12-14T18:22:41.000+0100}, title = {[Mechanisms of the regulation of adrenergic beta-receptors]}, url = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=9082678}, volume = {85 Suppl 7}, year = 1996 }