Abstract
The spectrophotometric kinetic methods are broadly used in the determination of drugs in several types of matrices. Thermal Lens Spectrometry (TLS) has demonstrated to be a sensitive indirect spectrophotometric technique used in the field of applied sciences, such as environmental and biochemical sciences. Ciclopirox olamine (OM) is a synthetic fungicide that inhibits the growth of pathogenic dermatophytes. This work presents the results of CXO determination by TLS, through a kinetic method, based on the CXO oxidation with KMnO4 in alkaline medium to form manganate (MnO42-). The Thermal Lens (TL) effect was generated by a He-Ne laser (TEM00, 20 mW, 632 nm). The TLS measurements were performed on a single beam assembly with a lens of f = 7.5 cm focal distance and 10 Hz modulation frequency. The TL signal from the detector was acquired for each sample. The optimization was at 30 min reaction time, KMnO4 8.0 . 10(-4) mol L-1 and Na2SO4 0.6 mol L-1. Under these conditions a calibration curve was constructed. The analytical features were LOD = 3.40 mu mol L-1 and LOQ = 113 mu mol L-1. To examine accuracy and reliability, the determination method was successfully applied in tap water samples where known amounts of CXO were spiked.
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