%0 Journal Article %1 weinkamer_towards_2019 %A Weinkamer, Richard %A Kollmannsberger, Philip %A Fratzl, Peter %D 2019 %J Current Osteoporosis Reports %K cctb computationalimageanalysis philipkollmannsberger %R 10.1007/s11914-019-00515-z %T Towards a Connectomic Description of the Osteocyte Lacunocanalicular Network in Bone %U https://doi.org/10.1007/s11914-019-00515-z %X Purpose of ReviewOsteocytes are the most abundant bone cells. They are completely encased in mineralized tissue, sitting inside lacunae that are connected by a multitude of canaliculi. In recent years, the osteocyte network has been shown to fulfill endocrine functions and to communicate with a number of other organs. This review addresses emerging knowledge on the connectome of the lacunocanalicular network in different types of bone tissue.Recent FindingsRecent advances in three-dimensional imaging technology started to reveal parameters that are well known from general theory to characterize the function of networks, such as network density, degree of nodes, or shortest path length through the network.SummaryThe connectome of the lacunocanalicular network differs in some aspects between lamellar and woven bone and seems to change with age. More research is needed to relate network structure to function, such as intercellular transport or communication and its role in mechanosensation, as well as to understand the effect of diseases.

@article{weinkamer_towards_2019, abstract = {Purpose of ReviewOsteocytes are the most abundant bone cells. They are completely encased in mineralized tissue, sitting inside lacunae that are connected by a multitude of canaliculi. In recent years, the osteocyte network has been shown to fulfill endocrine functions and to communicate with a number of other organs. This review addresses emerging knowledge on the connectome of the lacunocanalicular network in different types of bone tissue.Recent FindingsRecent advances in three-dimensional imaging technology started to reveal parameters that are well known from general theory to characterize the function of networks, such as network density, degree of nodes, or shortest path length through the network.SummaryThe connectome of the lacunocanalicular network differs in some aspects between lamellar and woven bone and seems to change with age. More research is needed to relate network structure to function, such as intercellular transport or communication and its role in mechanosensation, as well as to understand the effect of diseases.}, added-at = {2019-05-22T09:37:50.000+0200}, author = {Weinkamer, Richard and Kollmannsberger, Philip and Fratzl, Peter}, biburl = {https://www.bibsonomy.org/bibtex/2a31100d38934d3f0b9f36b4e93d34cbd/philipk}, doi = {10.1007/s11914-019-00515-z}, file = {Springer Full Text PDF:/Users/philip/Zotero/storage/SC49SBRF/Weinkamer et al. - 2019 - Towards a Connectomic Description of the Osteocyte.pdf:application/pdf}, interhash = {aa94f427ec28bea846958631dbd0d03b}, intrahash = {a31100d38934d3f0b9f36b4e93d34cbd}, issn = {1544-2241}, journal = {Current Osteoporosis Reports}, keywords = {cctb computationalimageanalysis philipkollmannsberger}, language = {en}, month = may, timestamp = {2019-05-22T09:37:50.000+0200}, title = {Towards a {Connectomic} {Description} of the {Osteocyte} {Lacunocanalicular} {Network} in {Bone}}, url = {https://doi.org/10.1007/s11914-019-00515-z}, urldate = {2019-05-21}, year = 2019 }