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Study of force-velocity dependence in molecular motors

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Abstract Book of the XXIII IUPAP International Conference on Statistical Physics, Genova, Italy, (9-13 July 2007)

Abstract

We analyze experimental information on the velocity of several molecular motors versus mechanical forces. We propose a general expression to match experimental data and to extract information about the relevance of the physico-chemical mechanisms involved. We apply this analysis to three different molecular motors: bacterial flagellar motor, kinesin-1 and RNA-polymerase (Fig. 1). These motors are measured under different types of load: conservative and nonconservative. They use also different energetic sources: nucleotide hydrolysis or electrochemical potentials. References: A. Ciudad and J.M. Sancho, External mechanical force as an inhibition process in kinesin's motion, Biochem. J. 390, 345 (2005) A. Ciudad and J.M. Sancho, A unified phenomenological approach to force-velocity curves in molecular motors, Preprint(2007)

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