Abstract
We analyze experimental information on the velocity of several molecular
motors versus mechanical forces. We propose a general expression to match
experimental data and to extract information about the relevance of the
physico-chemical mechanisms involved. We apply this analysis to three
different molecular motors: bacterial flagellar motor, kinesin-1 and RNA-polymerase (Fig. 1).
These motors are measured under different types of load: conservative and
nonconservative. They use also different energetic sources: nucleotide
hydrolysis or electrochemical potentials.
References:
A. Ciudad and J.M. Sancho, External mechanical force as an inhibition process
in kinesin's motion, Biochem. J. 390, 345 (2005)
A. Ciudad and J.M. Sancho, A unified phenomenological approach to
force-velocity curves in molecular motors, Preprint(2007)
Users
Please
log in to take part in the discussion (add own reviews or comments).