Abstract
An altered pattern of epigenetic modifications is central to many
common human diseases, including cancer. Many studies have explored
the mosaic patterns of DNA methylation and histone modification in
cancer cells on a gene-by-gene basis; among their results has been
the seminal finding of transcriptional silencing of tumour-suppressor
genes by CpG-island-promoter hypermethylation. However, recent technological
advances are now allowing cancer epigenetics to be studied genome-wide
- an approach that has already begun to provide both biological insight
and new avenues for translational research. It is time to 'upgrade'
cancer epigenetics research and put together an ambitious plan to
tackle the many unanswered questions in this field using epigenomics
approaches.
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