%0 Journal Article %1 cai2009pervasive %A Cai, James J. %A Macpherson, J. Michael %A Sella, Guy %A Petrov, Dmitri A. %D 2009 %I Public Library of Science %J PLoS Genet %K genome_wide_scan hitchhiking human_genome selection %N 1 %P e1000336 %R 10.1371/journal.pgen.1000336 %T Pervasive Hitchhiking at Coding and Regulatory Sites in Humans %U http://dx.doi.org/10.1371%2Fjournal.pgen.1000336 %V 5 %X <title>Author Summary</title> <p>There is much reported evidence for positive selection at specific loci in the human genome. Additional papers based on comparisons between the genomes of humans and chimpanzees have also suggested that adaptive evolution may be quite common. At the same time, it has been surprisingly hard to find unambiguous evidence that either positive or negative (background) selection is affecting genome-wide patterns of variation at neutral sites. Here, we evaluate the prevalence of positive or background selection by using two genome-wide datasets of human polymorphism. We document that levels of neutral polymorphism are substantially lower in the regions of (i) higher density of genes and/or regulatory regions, (ii) higher protein or regulatory divergence, and (iii) lower recombination. These patterns are robust to a number of possible confounding factors and suggest that effects of selection at linked sites cannot be ignored in the study of the human genome.</p>

@article{cai2009pervasive, abstract = {<title>Author Summary</title> <p>There is much reported evidence for positive selection at specific loci in the human genome. Additional papers based on comparisons between the genomes of humans and chimpanzees have also suggested that adaptive evolution may be quite common. At the same time, it has been surprisingly hard to find unambiguous evidence that either positive or negative (background) selection is affecting genome-wide patterns of variation at neutral sites. Here, we evaluate the prevalence of positive or background selection by using two genome-wide datasets of human polymorphism. We document that levels of neutral polymorphism are substantially lower in the regions of (i) higher density of genes and/or regulatory regions, (ii) higher protein or regulatory divergence, and (iii) lower recombination. These patterns are robust to a number of possible confounding factors and suggest that effects of selection at linked sites cannot be ignored in the study of the human genome.</p> }, added-at = {2010-03-29T00:20:41.000+0200}, author = {Cai, James J. and Macpherson, J. Michael and Sella, Guy and Petrov, Dmitri A.}, biburl = {https://www.bibsonomy.org/bibtex/2375164fc837afb4f9128c4d10fed8ce5/peter.ralph}, doi = {10.1371/journal.pgen.1000336}, interhash = {ae23b2ea4075b9f5d86d5612ecc1ac68}, intrahash = {375164fc837afb4f9128c4d10fed8ce5}, journal = {PLoS Genet}, keywords = {genome_wide_scan hitchhiking human_genome selection}, month = {01}, number = 1, pages = {e1000336}, publisher = {Public Library of Science}, timestamp = {2010-03-29T00:20:41.000+0200}, title = {Pervasive Hitchhiking at Coding and Regulatory Sites in Humans}, url = {http://dx.doi.org/10.1371%2Fjournal.pgen.1000336}, volume = 5, year = 2009 }