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The IBD process along four chromosomes

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Theor Popul Biol, 73 (3): 369-373 (мая 2008)
DOI: 10.1016/j.tpb.2007.11.011

Аннотация

In this note, we present the continuous-time Markov rate matrix that models identity by descent (ibd) patterns among four chromosomes in a population. The equilibrium distribution of this Markov process along a chromosome is the set of 4-gene state probabilities given by the Ewens sampling formula. This model will facilitate inference of identity by descent among the four chromosomes of a pair of individuals, using data at dense SNP loci among which there may be linkage disequilibrium.

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  • @peter.ralph

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