Аннотация
MapMan is a software tool that supports the visualization of profiling
data sets in the context of existing knowledge. Scavenger modules
generate hierarchical and essentially non-redundant gene ontologies
('mapping files'). An ImageAnnotator module visualizes the data on
a gene-by-gene basis on schematic diagrams ('maps') of biological
processes. The PageMan module uses the same ontologies to statistically
evaluate responses at the pathway or processes level. The generic
structure of MapMan also allows it to be used for transcripts, proteins,
enzymes and metabolites. MapMan was developed for use with Arabidopsis,
but has already been extended for use with several other species.
These tools are available as downloadable and web-based versions.
After providing an introduction to the scope and use of MapMan, we
present a case study where MapMan is used to analyse the transcriptional
response of the crop plant maize to diurnal changes and an extension
of the night. We then explain how MapMan can be customized to visually
and systematically compare responses in maize and Arabidopsis. These
analyses illustrate how MapMan can be used to analyse and compare
global transcriptional responses between phylogenetically distant
species, and show that analyses at the level of functional categories
are especially useful in cross-species comparisons.
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