%0 Journal Article %1 Isalan2008Evolvability %A Isalan, Mark %A Lemerle, Caroline %A Michalodimitrakis, Konstantinos %A Horn, Carsten %A Beltrao, Pedro %A Raineri, Emanuele %A Garriga-Canut, Mireia %A Serrano, Luis %D 2008 %I Nature Publishing Group %J Nature %K design-principles evolvability gene-networks network-evolution %N 7189 %P 840--845 %R 10.1038/nature06847 %T Evolvability and hierarchy in rewired bacterial gene networks %U http://dx.doi.org/10.1038/nature06847 %V 452 %X Sequencing DNA from several organisms has revealed that duplication and drift of existing genes have primarily moulded the contents of a given genome. Though the effect of knocking out or overexpressing a particular gene has been studied in many organisms, no study has systematically explored the effect of adding new links in a biological network. To explore network evolvability, we constructed 598 recombinations of promoters (including regulatory regions) with different transcription or sigma-factor genes in Escherichia coli, added over a wild-type genetic background. Here we show that approximately 95\% of new networks are tolerated by the bacteria, that very few alter growth, and that expression level correlates with factor position in the wild-type network hierarchy. Most importantly, we find that certain networks consistently survive over the wild type under various selection pressures. Therefore new links in the network are rarely a barrier for evolution and can even confer a fitness advantage.

@article{Isalan2008Evolvability, abstract = { Sequencing {DNA} from several organisms has revealed that duplication and drift of existing genes have primarily moulded the contents of a given genome. Though the effect of knocking out or overexpressing a particular gene has been studied in many organisms, no study has systematically explored the effect of adding new links in a biological network. To explore network evolvability, we constructed 598 recombinations of promoters (including regulatory regions) with different transcription or sigma-factor genes in Escherichia coli, added over a wild-type genetic background. Here we show that approximately 95\% of new networks are tolerated by the bacteria, that very few alter growth, and that expression level correlates with factor position in the wild-type network hierarchy. Most importantly, we find that certain networks consistently survive over the wild type under various selection pressures. Therefore new links in the network are rarely a barrier for evolution and can even confer a fitness advantage. }, added-at = {2018-12-02T16:09:07.000+0100}, author = {Isalan, Mark and Lemerle, Caroline and Michalodimitrakis, Konstantinos and Horn, Carsten and Beltrao, Pedro and Raineri, Emanuele and Garriga-Canut, Mireia and Serrano, Luis}, biburl = {https://www.bibsonomy.org/bibtex/2f8a82e13878101ab7c931e7a7c9ef531/karthikraman}, citeulike-article-id = {2678830}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/nature06847}, citeulike-linkout-1 = {http://dx.doi.org/10.1038/nature06847}, citeulike-linkout-2 = {http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2666274/}, citeulike-linkout-3 = {http://view.ncbi.nlm.nih.gov/pubmed/18421347}, citeulike-linkout-4 = {http://www.hubmed.org/display.cgi?uids=18421347}, day = 17, doi = {10.1038/nature06847}, interhash = {b94dffcddb0bd1fabb6209a866032873}, intrahash = {f8a82e13878101ab7c931e7a7c9ef531}, issn = {1476-4687}, journal = {Nature}, keywords = {design-principles evolvability gene-networks network-evolution}, month = apr, number = 7189, pages = {840--845}, pmcid = {PMC2666274}, pmid = {18421347}, posted-at = {2010-06-02 13:28:47}, priority = {2}, publisher = {Nature Publishing Group}, timestamp = {2018-12-02T16:09:07.000+0100}, title = {Evolvability and hierarchy in rewired bacterial gene networks}, url = {http://dx.doi.org/10.1038/nature06847}, volume = 452, year = 2008 }