Abstract
A probabilistic model is described for transmitter release from hair
cells, auditory neuron EPSP's, and discharge patterns. The model
assumes that the release fraction of the transmitter is a function
of stimulus intensity. It further assumes that some of this transmitter
substance is taken back into the cell while some is irretrievably
lost from the cleft. These assumptions differ from other recent models
which propose multiple release sites, fixed release fractions, and
no transmitter reuptake. The model produces realistic mammalian rate
intensity functions, interval and period histograms, incremental
responses, and adaptation effects. It mimics successfully the adaptation
of successive EPSP amplitudes of the afferent neuron of the goldfish
sacculus and offers a reinterpretation of the implications of these
studies for hair cell synaptic mechanism
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