Abstract
Cells integrate many inputs through complex networks of interacting
signaling pathways. Systems approaches as well as computer-aided
reductionist approaches attempt to üntangle the wires" and gain
an intimate understanding of cells. But ünderstanding" any system
is just the way that the human mind gains the ability to predict
behavior. Computer simulations are an alternative way to achieve
this goal--quite possibly the only way for complex systems. We have
new tools to probe large sets of unknown interactions, and we have
amassed enough detailed information to quantitatively describe many
functional modules. Cell physiology has passed the threshold: the
time to begin modeling is now.
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