%0 Journal Article %1 Mora_2005_169 %A Moraru, Ion I %A Loew, Leslie M %D 2005 %J Physiology (Bethesda) %K 15888574 Animals, Biological, Cells, Computer Eukaryotic Humans, Models, Signal Simulation, Transduction, %P 169--179 %R 10.1152/physiol.00052.2004 %T Intracellular signaling: spatial and temporal control. %U http://dx.doi.org/10.1152/physiol.00052.2004 %V 20 %X Cells integrate many inputs through complex networks of interacting signaling pathways. Systems approaches as well as computer-aided reductionist approaches attempt to üntangle the wires" and gain an intimate understanding of cells. But ünderstanding" any system is just the way that the human mind gains the ability to predict behavior. Computer simulations are an alternative way to achieve this goal--quite possibly the only way for complex systems. We have new tools to probe large sets of unknown interactions, and we have amassed enough detailed information to quantitatively describe many functional modules. Cell physiology has passed the threshold: the time to begin modeling is now.

@article{Mora_2005_169, abstract = {Cells integrate many inputs through complex networks of interacting signaling pathways. Systems approaches as well as computer-aided reductionist approaches attempt to "untangle the wires" and gain an intimate understanding of cells. But "understanding" any system is just the way that the human mind gains the ability to predict behavior. Computer simulations are an alternative way to achieve this goal--quite possibly the only way for complex systems. We have new tools to probe large sets of unknown interactions, and we have amassed enough detailed information to quantitatively describe many functional modules. Cell physiology has passed the threshold: the time to begin modeling is now.}, added-at = {2009-06-03T11:20:58.000+0200}, author = {Moraru, Ion I and Loew, Leslie M}, biburl = {https://www.bibsonomy.org/bibtex/2db3b6d8d94e8e51a0c123e69b0ae7040/hake}, description = {The whole bibliography file I use.}, doi = {10.1152/physiol.00052.2004}, file = {Mora_2005_169.pdf:Mora_2005_169.pdf:PDF}, interhash = {bca486dad1e1879d8713647d7f0211ab}, intrahash = {db3b6d8d94e8e51a0c123e69b0ae7040}, journal = {Physiology (Bethesda)}, key = 221, keywords = {15888574 Animals, Biological, Cells, Computer Eukaryotic Humans, Models, Signal Simulation, Transduction,}, month = Jun, pages = {169--179}, pii = {20/3/169}, pmid = {15888574}, timestamp = {2009-06-03T11:21:23.000+0200}, title = {Intracellular signaling: spatial and temporal control.}, url = {http://dx.doi.org/10.1152/physiol.00052.2004}, volume = 20, year = 2005 }