Аннотация
In the last decades we have witnessed a significant advance in protein
folding study and several theoretical models have been proposed with the
aim to elucidate the relationship between protein folding kinetics and
the structure of the native state (the functional state of the protein).
One of these, introduced in 1978 by Wako and Saitô and later reconsidered
by Muñoz and Eaton, is based on a lattice statistical mechanical model with
remarkable mathematical properties which make it possible to obtain exact
results.
In my poster I am going to discuss the Wako-Saitô-Muñoz-Eaton model of protein folding and its properties. I will illustrate equilibrium ones and then,
using these as a starting point, I will propose a way to treat the kinetic
problem that allows to reduce the computational complexity to polynomial,
from exponential in the number of aminoacids of the protein, and makes it
possible to obtain good semi-analytical approximation of its exact solution.
Some applications of exposed methods will be also considered.
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