%0 Book Section %1 statphys23_0774 %A Zamparo, M. %A Pelizzola, A. %A Imparato, A. %B Abstract Book of the XXIII IUPAP International Conference on Statistical Physics %C Genova, Italy %D 2007 %E Pietronero, Luciano %E Loreto, Vittorio %E Zapperi, Stefano %K folding lattice models protein solvable statphys23 topic-10 %T Wako-Saitô-Muñoz-Eaton Model and Protein Folding Kinetics %U http://st23.statphys23.org/webservices/abstract/preview_pop.php?ID_PAPER=774 %X In the last decades we have witnessed a significant advance in protein folding study and several theoretical models have been proposed with the aim to elucidate the relationship between protein folding kinetics and the structure of the native state (the functional state of the protein). One of these, introduced in 1978 by Wako and Saitô and later reconsidered by Muñoz and Eaton, is based on a lattice statistical mechanical model with remarkable mathematical properties which make it possible to obtain exact results. In my poster I am going to discuss the Wako-Saitô-Muñoz-Eaton model of protein folding and its properties. I will illustrate equilibrium ones and then, using these as a starting point, I will propose a way to treat the kinetic problem that allows to reduce the computational complexity to polynomial, from exponential in the number of aminoacids of the protein, and makes it possible to obtain good semi-analytical approximation of its exact solution. Some applications of exposed methods will be also considered.

@incollection{statphys23_0774, abstract = {In the last decades we have witnessed a significant advance in protein folding study and several theoretical models have been proposed with the aim to elucidate the relationship between protein folding kinetics and the structure of the native state (the functional state of the protein). One of these, introduced in 1978 by Wako and Sait\^{o} and later reconsidered by Mu\~{n}oz and Eaton, is based on a lattice statistical mechanical model with remarkable mathematical properties which make it possible to obtain exact results. In my poster I am going to discuss the Wako-Sait\^{o}-Mu\~{n}oz-Eaton model of protein folding and its properties. I will illustrate equilibrium ones and then, using these as a starting point, I will propose a way to treat the kinetic problem that allows to reduce the computational complexity to polynomial, from exponential in the number of aminoacids of the protein, and makes it possible to obtain good semi-analytical approximation of its exact solution. Some applications of exposed methods will be also considered.}, added-at = {2007-06-20T10:16:09.000+0200}, address = {Genova, Italy}, author = {Zamparo, M. and Pelizzola, A. and Imparato, A.}, biburl = {https://www.bibsonomy.org/bibtex/2953b74f7ab3779bb3bb21c536602e412/statphys23}, booktitle = {Abstract Book of the XXIII IUPAP International Conference on Statistical Physics}, editor = {Pietronero, Luciano and Loreto, Vittorio and Zapperi, Stefano}, interhash = {bd5e33de9850f45ecbb42c38c10c3f6c}, intrahash = {953b74f7ab3779bb3bb21c536602e412}, keywords = {folding lattice models protein solvable statphys23 topic-10}, month = {9-13 July}, timestamp = {2007-06-20T10:16:29.000+0200}, title = {Wako-Sait\^{o}-Mu\~{n}oz-Eaton Model and Protein Folding Kinetics}, url = {http://st23.statphys23.org/webservices/abstract/preview_pop.php?ID_PAPER=774}, year = 2007 }