Article,

Regulatory targets in the RNA polymerase II holoenzyme

, and .
Curr Opin Genet Dev, 8 (5): 565-570 (October 1998)

Abstract

The RNA polymerase II holoenzyme is the form of polymerase recruited to promoters for protein-coding genes. Several targets of mammalian activators, previously called coactivators, turn out to be subunits of the holoenzyme which activators use to recruit and regulate the holoenzyme. Several of these newly identified holoenzyme components have been implicated in human disease.

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