%0 Journal Article %1 Verheul.2007 %A Verheul, H. M. %A Pinedo, H. M. %D 2007 %J Nat.Rev.Cancer %K & A Administration Agents Angiogenesis Antineoplastic Biological Blood Clinical Coagulation Drug Endothelial Factor Function Growth Humans Hypertension Inhibitors Left Models Neoplasm Platelets Research Resistance Schedule Signal Thrombosis Topic Transduction Trials Vascular Ventricular administration adverse antagonists as chemically dosage drug effects etiology induced inhibitors physiology toxicity %N 6 %P 475-485 %T Possible molecular mechanisms involved in the toxicity of angiogenesis inhibition %U PM:17522716 %V 7 %X Contrary to initial expectations, angiogenesis inhibitors can cause toxicities in patients with cancer. The toxicity profiles of these inhibitors reflect the disturbance of growth factor signalling pathways that are important for maintaining homeostasis. Experiences with angiogenesis inhibitors in clinical trials indicate that short-term toxicities are mostly manageable. However, these agents will also be given in prolonged treatment strategies, so we need to anticipate possible long-term toxicities. In addition, understanding the molecular mechanisms involved in the toxicity of angiogenesis inhibition should allow more specific and more potent inhibitors to be developed

@article{Verheul.2007, abstract = {Contrary to initial expectations, angiogenesis inhibitors can cause toxicities in patients with cancer. The toxicity profiles of these inhibitors reflect the disturbance of growth factor signalling pathways that are important for maintaining homeostasis. Experiences with angiogenesis inhibitors in clinical trials indicate that short-term toxicities are mostly manageable. However, these agents will also be given in prolonged treatment strategies, so we need to anticipate possible long-term toxicities. In addition, understanding the molecular mechanisms involved in the toxicity of angiogenesis inhibition should allow more specific and more potent inhibitors to be developed}, added-at = {2010-02-05T11:28:39.000+0100}, author = {Verheul, H. M. and Pinedo, H. M.}, biburl = {https://www.bibsonomy.org/bibtex/2463d0b247e477cd3460c6d76976388b8/kanefendt}, interhash = {bf6f4748831751e1404fe909ebdf709d}, intrahash = {463d0b247e477cd3460c6d76976388b8}, journal = {Nat.Rev.Cancer}, keywords = {& A Administration Agents Angiogenesis Antineoplastic Biological Blood Clinical Coagulation Drug Endothelial Factor Function Growth Humans Hypertension Inhibitors Left Models Neoplasm Platelets Research Resistance Schedule Signal Thrombosis Topic Transduction Trials Vascular Ventricular administration adverse antagonists as chemically dosage drug effects etiology induced inhibitors physiology toxicity}, number = 6, pages = {475-485}, timestamp = {2010-02-05T11:28:54.000+0100}, title = {Possible molecular mechanisms involved in the toxicity of angiogenesis inhibition}, url = {PM:17522716}, volume = 7, year = 2007 }