%0 Journal Article %1 RN4 %A Arrau, S. %A Delporte, C. %A Cartagena, C. %A Rodriguez-Diaz, M. %A Gonzalez, P. %A Silva, X. %A Cassels, B.K. %A Miranda, H.F. %D 2011 %I 2010 Elsevier Ireland Ltd. %J Journal of Ethnopharmacology %K acid acid, activity, acute analgesia, analgesic assay, derivatives, dqcauchile drugs hot-plate models, pain, quillaic quillaja saponaria, tail-flick %N 1 %P 164-167 %R 10.1016/j.jep.2010.09.016 %T Antinociceptive Activity of Quillaja Saponaria Mol. Saponin Extract, Quillaic Acid and Derivatives in Mice %U /brokenurl#<Go to ISI>://WOS:000286854100023 %V 133 %X Ethnopharmacological relevance: Quillaja saponaria bark contains a high percentage of triterpene saponins and has been used for centuries as a cleansing and analgesic agent in Chilean folk medicine., Aim of the study: The topical and systemic analgesic effects of a commercial partially purified saponin extract, 3 beta,16 alpha-dihydroxy-23-oxoolean-12-en-28-oic acid (quillaic acid), methyl 3 beta,16 alpha-dihydroxy-23-oxoolean-12-en-28-oate and methyl 4-nor-3,16-dioxoolean-12-en-28-oate., Materials and methods: The samples were assessed in mice using the topical tail-flick and i.p. hot-plate tests, respectively., Results: All the samples showed activity in both analgesic tests in a dose-dependent manner. The most active against tail flick test was commercial partially purified saponin extract (EC50 27.9 mg%, w/v) and more than the ibuprofen sodium. On hot-plate test, methyl 4-nor-3, 16-dioxoolean-12-en-28-oate was the most active (ED50 12.2 mg/kg) and more than the ibuprofen sodium., Conclusions: The results of the present study demonstrated that Quillaja saponaria saponins, quillaic acid, its methyl ester, and one of the oxidized derivatives of the latter, elicit dose-dependent antinociceptive effects in two murine thermal models.

@article{RN4, abstract = {Ethnopharmacological relevance: Quillaja saponaria bark contains a high percentage of triterpene saponins and has been used for centuries as a cleansing and analgesic agent in Chilean folk medicine., Aim of the study: The topical and systemic analgesic effects of a commercial partially purified saponin extract, 3 beta,16 alpha-dihydroxy-23-oxoolean-12-en-28-oic acid (quillaic acid), methyl 3 beta,16 alpha-dihydroxy-23-oxoolean-12-en-28-oate and methyl 4-nor-3,16-dioxoolean-12-en-28-oate., Materials and methods: The samples were assessed in mice using the topical tail-flick and i.p. hot-plate tests, respectively., Results: All the samples showed activity in both analgesic tests in a dose-dependent manner. The most active against tail flick test was commercial partially purified saponin extract (EC50 27.9 mg%, w/v) and more than the ibuprofen sodium. On hot-plate test, methyl 4-nor-3, 16-dioxoolean-12-en-28-oate was the most active (ED50 12.2 mg/kg) and more than the ibuprofen sodium., Conclusions: The results of the present study demonstrated that Quillaja saponaria saponins, quillaic acid, its methyl ester, and one of the oxidized derivatives of the latter, elicit dose-dependent antinociceptive effects in two murine thermal models. }, added-at = {2019-12-04T03:57:35.000+0100}, author = {Arrau, S. and Delporte, C. and Cartagena, C. and Rodriguez-Diaz, M. and Gonzalez, P. and Silva, X. and Cassels, B.K. and Miranda, H.F.}, biburl = {https://www.bibsonomy.org/bibtex/2ffe6977aa4c32b2d23f21b987b830d2f/dqcauchile}, doi = {10.1016/j.jep.2010.09.016}, interhash = {c47665961b89c46828d263422d7359fc}, intrahash = {ffe6977aa4c32b2d23f21b987b830d2f}, issn = {0378-8741}, journal = {Journal of Ethnopharmacology}, keywords = {acid acid, activity, acute analgesia, analgesic assay, derivatives, dqcauchile drugs hot-plate models, pain, quillaic quillaja saponaria, tail-flick}, number = 1, pages = {164-167}, publisher = {2010 Elsevier Ireland Ltd.}, timestamp = {2019-12-04T03:58:17.000+0100}, title = {Antinociceptive Activity of Quillaja Saponaria Mol. Saponin Extract, Quillaic Acid and Derivatives in Mice}, type = {Journal Article}, url = {/brokenurl#<Go to ISI>://WOS:000286854100023}, volume = 133, year = 2011 }