Abstract
Cephalosporins are among the most frequently used broad-spectrum
antimicrobial agents. Ceftazidime is a semisynthetic beta-lactam
antibiotic for parenteral administration widely used in the clinical
practice, which has been categorized as a third-generation cephalosporin
antibiotic. This drug crystallizes as a pentahydrate and, as all
cephalosporins, it is unstable and subject to hydrolytic degradation.
Taking this into account, this study investigates the stability under 2
different conditions (high temperature and exposition to vacuum) by
using various techniques, as thermal analysis, Raman spectroscopy, and
X-ray powder diffraction supported by multivariate curve resolution. It
was proved that ceftazidime pentahydrate is unstable under the studied
variables, exhibiting several transformation processes, which were
discussed in terms of the crystalline structure. (c) 2020 American
Pharmacists Association (R). Published by Elsevier Inc. All rights
reserved.
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