%0 Journal Article %1 WOS:000514848500013 %A de Santana, Maria Silmara Alves %A de Oliveira, Yara Santiago %A de Fonseca, Jessica Castro %A Ferreira, Wellington Castro %A Neto, Vasco Stascxak %A Ayala, Alejandro Pedro %C STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA %D 2020 %I ELSEVIER SCIENCE INC %J JOURNAL OF PHARMACEUTICAL SCIENCES %K analysis} cephalosporin; pentahydrate; stability; thermal {ceftazidime %N 3 %P 1324-1329 %R 10.1016/j.xphs.2019.11.018 %T Stability of Ceftazidime Pentahydrate Investigated by Thermal Analysis Techniques %V 109 %X Cephalosporins are among the most frequently used broad-spectrum antimicrobial agents. Ceftazidime is a semisynthetic beta-lactam antibiotic for parenteral administration widely used in the clinical practice, which has been categorized as a third-generation cephalosporin antibiotic. This drug crystallizes as a pentahydrate and, as all cephalosporins, it is unstable and subject to hydrolytic degradation. Taking this into account, this study investigates the stability under 2 different conditions (high temperature and exposition to vacuum) by using various techniques, as thermal analysis, Raman spectroscopy, and X-ray powder diffraction supported by multivariate curve resolution. It was proved that ceftazidime pentahydrate is unstable under the studied variables, exhibiting several transformation processes, which were discussed in terms of the crystalline structure. (c) 2020 American Pharmacists Association (R). Published by Elsevier Inc. All rights reserved.

@article{WOS:000514848500013, abstract = {Cephalosporins are among the most frequently used broad-spectrum antimicrobial agents. Ceftazidime is a semisynthetic beta-lactam antibiotic for parenteral administration widely used in the clinical practice, which has been categorized as a third-generation cephalosporin antibiotic. This drug crystallizes as a pentahydrate and, as all cephalosporins, it is unstable and subject to hydrolytic degradation. Taking this into account, this study investigates the stability under 2 different conditions (high temperature and exposition to vacuum) by using various techniques, as thermal analysis, Raman spectroscopy, and X-ray powder diffraction supported by multivariate curve resolution. It was proved that ceftazidime pentahydrate is unstable under the studied variables, exhibiting several transformation processes, which were discussed in terms of the crystalline structure. (c) 2020 American Pharmacists Association (R). Published by Elsevier Inc. All rights reserved.}, added-at = {2022-05-23T20:00:14.000+0200}, address = {STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA}, author = {de Santana, Maria Silmara Alves and de Oliveira, Yara Santiago and de Fonseca, Jessica Castro and Ferreira, Wellington Castro and Neto, Vasco Stascxak and Ayala, Alejandro Pedro}, biburl = {https://www.bibsonomy.org/bibtex/2af9fcd12fba5439c4a579bb0f5b9e5c1/ppgfis_ufc_br}, doi = {10.1016/j.xphs.2019.11.018}, interhash = {c86ba01eff7509538fc3db6761ea3305}, intrahash = {af9fcd12fba5439c4a579bb0f5b9e5c1}, issn = {0022-3549}, journal = {JOURNAL OF PHARMACEUTICAL SCIENCES}, keywords = {analysis} cephalosporin; pentahydrate; stability; thermal {ceftazidime}, number = 3, pages = {1324-1329}, publisher = {ELSEVIER SCIENCE INC}, pubstate = {published}, timestamp = {2022-05-23T20:00:14.000+0200}, title = {Stability of Ceftazidime Pentahydrate Investigated by Thermal Analysis Techniques}, tppubtype = {article}, volume = 109, year = 2020 }