Abstract
The past year has seen several sets of experimental results demonstrate
that fast, large and highly localized rises in intracellular Ca$^2+$
concentration can occur in neurons. These results confirm previous
theoretical predictions of acute spatial compartmentalization of
Ca$^2+$ signalling, and document a form of signalling that may
occur whenever rapid and local signal processing is the goal. The
dimensions involved present severe challenges for attempts to directly
measure these signalling events.
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