Abstract
Quantitative modeling indicates that, in presynaptic terminals, the
intracellular calcium concentration profile during inward calcium
current is characterized by discrete peaks of calcium immediately
adjacent to the calcium channels. This restriction of intracellular
calcium concentration suggests a remarkably well specified intracellular
architecture such that calcium, as a second messenger, may regulate
particular intracellular domains with a great degree of specificity.
- 2412607
- animals,
- biological,
- calcium,
- channels,
- comparative
- cytosol,
- diffusion,
- gov't,
- ion
- kinetics,
- membrane
- models,
- p.h.s.,
- potentials,
- research
- software,
- squid,
- study,
- support,
- synapses,
- u.s.
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