%0 Journal Article %1 Otani:2018:Cancer-Sci:29752851 %A Otani, R %A Uzuka, T %A Higuchi, F %A Matsuda, H %A Nomura, M %A Tanaka, S %A Mukasa, A %A Ichimura, K %A Kim, P %A Ueki, K %D 2018 %J Cancer Sci %K IDH SHOULDREAD astrocytoma cancer-research glioblastoma paywall tcga %R 10.1111/cas.13635 %T IDH-mutated astrocytomas with 19q-loss constitute a subgroup that confers better prognosis %U https://www.ncbi.nlm.nih.gov/pubmed/29752851 %X IDH-mutant gliomas are classified into astrocytic or oligodendroglial tumors by 1p/19q status in WHO 2016 classification, with the latter presenting with characteristic morphology and better prognosis in general. However, the morphological and genetic features within each category are varied, and there may be distinguishable subtypes. We analyzed 170 WHO grade II to IV gliomas resected in our institution. 1p/19q status was analyzed by microsatellite analysis, and genetic mutations were analyzed by next-generation sequencing and Sanger sequencing. For validation, the Brain Lower Grade Glioma dataset of the TCGA was analyzed. Of the 42 grade III IDH-mutated gliomas, 12 were 1p-intact/19q-intact (anaplastic astrocytomas: AA), 7 were 1p-intact/19q-loss (AA), and 23 showed 1p/19q-codeletion (anaplastic oligodendrogliomas: AO). Of the 88 IDH-wild type GBMs, 14 showed 1p-intact/19q-loss status. All of the seven 1p-intact/19q-loss AAs harbored TP53 mutation, but no TERT promotor mutation. All 19q-loss AAs had regions presenting oligodendroglioma-like morphology, and were associated with significantly longer overall survival (OS) compared to 19q-intact AAs (p=0.001). This tendency was observed in the TCGA Lower Grade Glioma dataset. In contrast, there was no difference in OS between the 19q-loss GBM and 19q-intact GBM (p=0.4). In a case of 19q-loss AA, both oligodendroglial morphology and 19q-loss disappeared after recurrence, possibly indicating correlation between 19q-loss and oligodendroglial morphology. We showed that there was a subgroup, although small, of IDH-mutated astrocytomas harboring 19q-loss that present oligodendroglial morphology, and also were associated with significantly better prognosis compared to other 19q-intact astrocytomas. This article is protected by copyright. All rights reserved.

@article{Otani:2018:Cancer-Sci:29752851, abstract = {IDH-mutant gliomas are classified into astrocytic or oligodendroglial tumors by 1p/19q status in WHO 2016 classification, with the latter presenting with characteristic morphology and better prognosis in general. However, the morphological and genetic features within each category are varied, and there may be distinguishable subtypes. We analyzed 170 WHO grade II to IV gliomas resected in our institution. 1p/19q status was analyzed by microsatellite analysis, and genetic mutations were analyzed by next-generation sequencing and Sanger sequencing. For validation, the Brain Lower Grade Glioma dataset of the TCGA was analyzed. Of the 42 grade III IDH-mutated gliomas, 12 were 1p-intact/19q-intact (anaplastic astrocytomas: AA), 7 were 1p-intact/19q-loss (AA), and 23 showed 1p/19q-codeletion (anaplastic oligodendrogliomas: AO). Of the 88 IDH-wild type GBMs, 14 showed 1p-intact/19q-loss status. All of the seven 1p-intact/19q-loss AAs harbored TP53 mutation, but no TERT promotor mutation. All 19q-loss AAs had regions presenting oligodendroglioma-like morphology, and were associated with significantly longer overall survival (OS) compared to 19q-intact AAs (p=0.001). This tendency was observed in the TCGA Lower Grade Glioma dataset. In contrast, there was no difference in OS between the 19q-loss GBM and 19q-intact GBM (p=0.4). In a case of 19q-loss AA, both oligodendroglial morphology and 19q-loss disappeared after recurrence, possibly indicating correlation between 19q-loss and oligodendroglial morphology. We showed that there was a subgroup, although small, of IDH-mutated astrocytomas harboring 19q-loss that present oligodendroglial morphology, and also were associated with significantly better prognosis compared to other 19q-intact astrocytomas. This article is protected by copyright. All rights reserved.}, added-at = {2018-05-18T20:24:16.000+0200}, author = {Otani, R and Uzuka, T and Higuchi, F and Matsuda, H and Nomura, M and Tanaka, S and Mukasa, A and Ichimura, K and Kim, P and Ueki, K}, biburl = {https://www.bibsonomy.org/bibtex/2c8ec0d7b0467b5254cb14ebe185569b7/marcsaric}, description = {IDH-mutated astrocytomas with 19q-loss constitute a subgroup that confers better prognosis. - PubMed - NCBI}, doi = {10.1111/cas.13635}, interhash = {d8f764e087679ab165fecb2743907a04}, intrahash = {c8ec0d7b0467b5254cb14ebe185569b7}, journal = {Cancer Sci}, keywords = {IDH SHOULDREAD astrocytoma cancer-research glioblastoma paywall tcga}, month = may, pmid = {29752851}, timestamp = {2018-05-18T20:24:16.000+0200}, title = {IDH-mutated astrocytomas with 19q-loss constitute a subgroup that confers better prognosis}, url = {https://www.ncbi.nlm.nih.gov/pubmed/29752851}, year = 2018 }