%0 Journal Article %1 Zhang2009TargetResidenceTime %A Zhang, R %A Monsma, F %D 2009 %J Curr Opin Drug Discov Devel %K drug-design residence-time %N 4 %P 488-496 %T The importance of drug-target residence time %U http://europepmc.org/abstract/med/19562645 %V 12 %X The importance of kinetics in drug-target interactions, and particularly the residence time of a drug with its target, is increasingly recognized to play a pivotal role in determining both the efficacy and toxicity of a drug. Drug residence time can often be demonstrated to be a key differentiating factor between drugs that act upon a common target. Drug-target residence time can result in either favorable or unfavorable outcomes, and the use of such information could lead to the more efficient design of best-in-class drugs. This review highlights several key concepts and observations related to drug-target residence time, and suggests the use of a kinetics-perceptive and energetics-informed approach to address the challenges facing current drug discovery efforts.

@article{Zhang2009TargetResidenceTime, abstract = {The importance of kinetics in drug-target interactions, and particularly the residence time of a drug with its target, is increasingly recognized to play a pivotal role in determining both the efficacy and toxicity of a drug. Drug residence time can often be demonstrated to be a key differentiating factor between drugs that act upon a common target. Drug-target residence time can result in either favorable or unfavorable outcomes, and the use of such information could lead to the more efficient design of best-in-class drugs. This review highlights several key concepts and observations related to drug-target residence time, and suggests the use of a kinetics-perceptive and energetics-informed approach to address the challenges facing current drug discovery efforts.}, added-at = {2017-03-10T02:38:17.000+0100}, author = {Zhang, R and Monsma, F}, biburl = {https://www.bibsonomy.org/bibtex/211567bec61f91e5234be6cd47ed0e86a/salotz}, description = {The importance of drug-target residence time. - Abstract - Europe PMC}, interhash = {e04a932fbd69f42fe4dbeaba763ca915}, intrahash = {11567bec61f91e5234be6cd47ed0e86a}, journal = {Curr Opin Drug Discov Devel}, keywords = {drug-design residence-time}, month = jul, note = {Can't find the full text of this}, number = 4, pages = {488-496}, pmid = {19562645}, timestamp = {2017-03-10T02:38:17.000+0100}, title = {The importance of drug-target residence time}, url = {http://europepmc.org/abstract/med/19562645}, volume = 12, year = 2009 }