Incollection,

Intra-cellular traffic: bio-molecular motors on filamentary tracks

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Abstract Book of the XXIII IUPAP International Conference on Statistical Physics, Genova, Italy, (9-13 July 2007)

Abstract

Molecular motors are macromolecular complexes which use some form of input energy to perform mechanical work. The filamentary tracks, on which these motors move, are made of either proteins (e.g., microtubules) or nucleic acids (DNA or RNA). Often, many such motors move simultaneously on the same track and their collective properties have several superficial similarities with vehicular traffic on highways. After introducing the fundamental physical principles underlying the mechanisms of operation of individual motors, I'll consider a few specific examples of molecular motor traffic. The models we have developed 1-6 provide ``unified'' description: in the low-density limit, a model captures the transport properties of a single motor while, at higher densities the same model accounts for the collective spatio-temporal dynamics of interacting motors. We show how the intra-cellular molecular motor traffic phenomena depend on the mechano-chemistry of the corresponding individual motors 7. 1) A. Basu and D. Chowdhury, Phys. Rev. E, 75, 021902 (2007). \\ 2) A. Basu and D. Chowdhury, submitted for publication (e-print: physics/0702149).\\ 3) A. Basu, D. Chowdhury, A. Garai and T.V. Ramakrishnan, to be published (2007).\\ 4) T. Tripathi and D. Chowdhury, submitted for publication (2007).\\ 5) K. Nishinari, Y. Okada, A. Schadschneider and D. Chowdhury, Phys. Rev. Lett. 95, 118101 (2005).\\ 6) P. Greulich, A. Garai, K. Nishinari, A. Schadschneider and D. Chowdhury, accepted for publication in Phys. Rev. E (2007).\\ 7) D. Chowdhury, P.K. Mishra, K. Nishinari and A. Schadschneider, to be published, (2007).

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