%0 Journal Article %1 Levin2010Specific %A Levin, Aviad %A Hayouka, Zvi %A Friedler, Assaf %A Loyter, Abraham %D 2010 %J AIDS Research and Therapy %K hiv therapeutic-strategies %N 1 %P 31+ %R 10.1186/1742-6405-7-31 %T Specific eradication of HIV-1 from infected cultured cells %U http://dx.doi.org/10.1186/1742-6405-7-31 %V 7 %X A correlation between increase in the integration of Human Immunodeficiency virus-1 (HIV-1) cDNA and cell death was previously established. Here we show that combination of peptides that stimulate integration together with the protease inhibitor Ro 31-8959 caused apoptotic cell death of HIV infected cells with total extermination of the virus. This combination did not have any effect on non-infected cells. Thus it appears that cell death is promoted only in the infected cells. It is our view that the results described in this work suggest a novel approach to specifically promote death of HIV-1 infected cells and thus may eventually be developed into a new and general anti-viral therapy.

@article{Levin2010Specific, abstract = {A correlation between increase in the integration of Human Immunodeficiency virus-1 ({HIV}-1) {cDNA} and cell death was previously established. Here we show that combination of peptides that stimulate integration together with the protease inhibitor Ro 31-8959 caused apoptotic cell death of {HIV} infected cells with total extermination of the virus. This combination did not have any effect on non-infected cells. Thus it appears that cell death is promoted only in the infected cells. It is our view that the results described in this work suggest a novel approach to specifically promote death of {HIV}-1 infected cells and thus may eventually be developed into a new and general anti-viral therapy.}, added-at = {2018-12-02T16:09:07.000+0100}, author = {Levin, Aviad and Hayouka, Zvi and Friedler, Assaf and Loyter, Abraham}, biburl = {https://www.bibsonomy.org/bibtex/2e7621a09986b40ab9ab86f8db2c52cb0/karthikraman}, citeulike-article-id = {7680650}, citeulike-linkout-0 = {http://dx.doi.org/10.1186/1742-6405-7-31}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/20723214}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=20723214}, doi = {10.1186/1742-6405-7-31}, interhash = {e670c8bf98c0a5f8799d68ed8d823d46}, intrahash = {e7621a09986b40ab9ab86f8db2c52cb0}, issn = {1742-6405}, journal = {AIDS Research and Therapy}, keywords = {hiv therapeutic-strategies}, number = 1, pages = {31+}, pmid = {20723214}, posted-at = {2010-09-03 11:02:33}, priority = {2}, timestamp = {2018-12-02T16:09:07.000+0100}, title = {Specific eradication of {HIV}-1 from infected cultured cells}, url = {http://dx.doi.org/10.1186/1742-6405-7-31}, volume = 7, year = 2010 }