%0 Journal Article %1 Inotsume1986 %A Inotsume, N. %A Higashi, A. %A Matsukane, I. %A Chikazawa, S. %A Nakano, M. %A Matsuda, I. %D 1986 %J Pediatr Pharmacol (New York) %K Adolescent; Adult; Cerebral Palsy; Child; Child, Preschool; Dantrolene; Dose-Response Relationship, Drug; Female; Humans; Kinetics; Male; Metabolic Clearance Rate %N 4 %P 253--259 %T Relationship between serum concentration and daily dose of dantrolene in cerebral palsy patients. %V 5 %X Serum concentration of dantrolene and its active metabolite, 5-hydroxydantrolene were determined in 27 cerebral palsy patients. Correlation coefficients between the oral dose of dantrolene and serum levels of dantrolene and its major metabolite, 5-hydroxydantrolene were rather small in cerebral palsy patients. The mean half-times of dantrolene and 5-hydroxydantrolene were 3.41 (n = 6) and 4.00 (n = 5) hours, respectively. These values were about a half of those reported earlier Lietman et al., 1974; Meyler et al., 1979; Flewellen et al., 1983. The poor correlation between serum level and dose may be due to the variation in an extent of oral dantrolene availability.

@article{Inotsume1986, abstract = {Serum concentration of dantrolene and its active metabolite, 5-hydroxydantrolene were determined in 27 cerebral palsy patients. Correlation coefficients between the oral dose of dantrolene and serum levels of dantrolene and its major metabolite, 5-hydroxydantrolene were rather small in cerebral palsy patients. The mean half-times of dantrolene and 5-hydroxydantrolene were 3.41 (n = 6) and 4.00 (n = 5) hours, respectively. These values were about a half of those reported earlier [Lietman et al., 1974; Meyler et al., 1979; Flewellen et al., 1983]. The poor correlation between serum level and dose may be due to the variation in an extent of oral dantrolene availability.}, added-at = {2014-07-19T20:29:36.000+0200}, author = {Inotsume, N. and Higashi, A. and Matsukane, I. and Chikazawa, S. and Nakano, M. and Matsuda, I.}, biburl = {https://www.bibsonomy.org/bibtex/2c5f17f1e5b9ad52ef796b6df58d720af/ar0berts}, groups = {public}, interhash = {e83e8defeaa5838541e85278d8318a6d}, intrahash = {c5f17f1e5b9ad52ef796b6df58d720af}, journal = {Pediatr Pharmacol (New York)}, keywords = {Adolescent; Adult; Cerebral Palsy; Child; Child, Preschool; Dantrolene; Dose-Response Relationship, Drug; Female; Humans; Kinetics; Male; Metabolic Clearance Rate}, number = 4, pages = {253--259}, pmid = {3737270}, timestamp = {2014-07-19T20:29:36.000+0200}, title = {Relationship between serum concentration and daily dose of dantrolene in cerebral palsy patients.}, username = {ar0berts}, volume = 5, year = 1986 }