%0 Journal Article %1 Gyoer_2002_d1454 %A Gy�rke, Sandor %A Gy�rke, Inna %A Lukyanenko, Valeriy %A Terentyev, Dmitriy %A Viatchenko-Karpinski, Serge %A Wiesner, Theodore F %D 2002 %J Front Biosci %K 12045014 Animals, Calcium Calcium, Channels, Gov't, Heart, Humans, Myocardium, Non-U.S. P.H.S., Research Reticulum, Sarcoplasmic Support, U.S. %P d1454--d1463 %T Regulation of sarcoplasmic reticulum calcium release by luminal calcium in cardiac muscle. %U http://www.bioscience.org/2002/v7/d/gyorke/list.htm %V 7 %X The amount of Ca$^2+$ released from the sarcoplasmic reticulum (SR) is a principal determinant of cardiac contractility. Normally, the SR Ca$^2+$ stores are mobilized through the mechanism of Ca$^2+$-induced Ca$^2+$ release (CICR). In this process, Ca$^2+$ enters the cell through plasmalemmal voltage-dependent Ca$^2+$ channels to activate the Ca$^2+$ release channels in the SR membrane. Consequently, the control of Ca$^2+$ release by cytosolic Ca$^2+$ has traditionally been the main focus of cardiac excitation-contraction (EC) coupling research. Evidence obtained recently suggests that SR Ca release is controlled not only by cytosolic Ca$^2+$, but also by Ca$^2+$ in the lumen of the SR. The presence of a luminal Ca$^2+$ sensor regulating release of SR luminal Ca$^2+$ potentially has profound implications for our understanding of EC coupling and intracellular Ca$^2+$ cycling. Here we review evidence, obtained using in situ and in vitro approaches, in support of such a luminal Ca$^2+$ sensor in cardiac muscle. We also discuss the role of control of Ca$^2+$ release channels by luminal Ca$^2+$ in termination and stabilization of CICR, as well as in shaping the response of cardiac myocytes to various inotropic influences and diseased states such as Ca$^2+$ overload and heart failure.

@article{Gyoer_2002_d1454, abstract = {The amount of {C}a$^{2+}$ released from the sarcoplasmic reticulum (SR) is a principal determinant of cardiac contractility. Normally, the SR {C}a$^{2+}$ stores are mobilized through the mechanism of {C}a$^{2+}$-induced {C}a$^{2+}$ release (CICR). In this process, {C}a$^{2+}$ enters the cell through plasmalemmal voltage-dependent {C}a$^{2+}$ channels to activate the {C}a$^{2+}$ release channels in the SR membrane. Consequently, the control of {C}a$^{2+}$ release by cytosolic {C}a$^{2+}$ has traditionally been the main focus of cardiac excitation-contraction (EC) coupling research. Evidence obtained recently suggests that SR Ca release is controlled not only by cytosolic {C}a$^{2+}$, but also by {C}a$^{2+}$ in the lumen of the SR. The presence of a luminal {C}a$^{2+}$ sensor regulating release of SR luminal {C}a$^{2+}$ potentially has profound implications for our understanding of EC coupling and intracellular {C}a$^{2+}$ cycling. Here we review evidence, obtained using in situ and in vitro approaches, in support of such a luminal {C}a$^{2+}$ sensor in cardiac muscle. We also discuss the role of control of {C}a$^{2+}$ release channels by luminal {C}a$^{2+}$ in termination and stabilization of CICR, as well as in shaping the response of cardiac myocytes to various inotropic influences and diseased states such as {C}a$^{2+}$ overload and heart failure.}, added-at = {2009-06-03T11:20:58.000+0200}, author = {Gy�rke, Sandor and Gy�rke, Inna and Lukyanenko, Valeriy and Terentyev, Dmitriy and Viatchenko-Karpinski, Serge and Wiesner, Theodore F}, biburl = {https://www.bibsonomy.org/bibtex/21e4fe61ff5e8aa45d23a0b54579084fc/hake}, description = {The whole bibliography file I use.}, file = {Gyoer_2002_d1454.pdf:Gyoer_2002_d1454.pdf:PDF}, interhash = {e91512e22a5a73d48b7b2f673dbc04be}, intrahash = {1e4fe61ff5e8aa45d23a0b54579084fc}, journal = {Front Biosci}, key = 190, keywords = {12045014 Animals, Calcium Calcium, Channels, Gov't, Heart, Humans, Myocardium, Non-U.S. P.H.S., Research Reticulum, Sarcoplasmic Support, U.S.}, month = Jun, pages = {d1454--d1463}, pmid = {12045014}, timestamp = {2009-06-03T11:21:13.000+0200}, title = {Regulation of sarcoplasmic reticulum calcium release by luminal calcium in cardiac muscle.}, url = {http://www.bioscience.org/2002/v7/d/gyorke/list.htm}, volume = 7, year = 2002 }