%0 Journal Article %1 RN134 %A Garcia-Toro, M. %A Aguilar-Latorre, A. %A Garcia, A. %A Navarro-Guzmán, C. %A Gervilla, E. %A Seguí, A. %A Gazquez, F. %A Marino, J. A. %A Gomez-Juanes, R. %A Serrano-Ripoll, M. J. %A Oliván-Blázquez, B. %A Garcia-Campayo, J. %A Maloney, S. %A Montero-Marin, J. %D 2023 %J Front Psychol %K grapp-caib %P 1008891 %R 10.3389/fpsyg.2023.1008891 %T Mindfulness skills and experiential avoidance as therapeutic mechanisms for treatment-resistant depression through mindfulness-based cognitive therapy and lifestyle modification %V 14 %X BACKGROUND/OBJECTIVE: The COVID-19 pandemic and consequent physical distancing has made it difficult to provide care for those with Treatment-Resistant Depression (TRD). As a secondary analysis of a clinical trial, the aim of this study was to explore potential mechanisms through which three online-delivered approaches, added to treatment as usual, improve depressive symptoms in TRD patients. METHODS: The three approaches included (a) Minimal Lifestyle Intervention (MLI), (b) Mindfulness-Based Cognitive Therapy (MBCT), and (c) Lifestyle Modification Program (LMP). Sixty-six participants with TRD completed assessments pre-post intervention (mindfulness skills FFMQ; self-compassion SCS; and experiential avoidance AAQ-II) and pre-intervention to follow-up (depressive symptoms BDI-II). Data were analyzed using within-subjects regression models to test mediation. RESULTS: Mindfulness skills mediated the effect of MBCT on depressive symptoms (ab = -4.69, 95% CI = -12.93 to-0.32), whereas the lack of experiential avoidance mediated the effect of LMP on depressive symptoms (ab = -3.22, 95% CI = -7.03 to-0.14). CONCLUSION: Strengthening mindfulness skills and decreasing experiential avoidance may promote recovery in patients with TRD, MBCT, and LMP have demonstrated that they may help increase mindfulness skills and decrease experiential avoidance, respectively. Future work will need to unpick the components of these interventions to help isolate active ingredients and increase optimization.

@article{RN134, abstract = {BACKGROUND/OBJECTIVE: The COVID-19 pandemic and consequent physical distancing has made it difficult to provide care for those with Treatment-Resistant Depression (TRD). As a secondary analysis of a clinical trial, the aim of this study was to explore potential mechanisms through which three online-delivered approaches, added to treatment as usual, improve depressive symptoms in TRD patients. METHODS: The three approaches included (a) Minimal Lifestyle Intervention (MLI), (b) Mindfulness-Based Cognitive Therapy (MBCT), and (c) Lifestyle Modification Program (LMP). Sixty-six participants with TRD completed assessments pre-post intervention (mindfulness skills [FFMQ]; self-compassion [SCS]; and experiential avoidance [AAQ-II]) and pre-intervention to follow-up (depressive symptoms [BDI-II]). Data were analyzed using within-subjects regression models to test mediation. RESULTS: Mindfulness skills mediated the effect of MBCT on depressive symptoms (ab = -4.69, 95% CI = -12.93 to-0.32), whereas the lack of experiential avoidance mediated the effect of LMP on depressive symptoms (ab = -3.22, 95% CI = -7.03 to-0.14). CONCLUSION: Strengthening mindfulness skills and decreasing experiential avoidance may promote recovery in patients with TRD, MBCT, and LMP have demonstrated that they may help increase mindfulness skills and decrease experiential avoidance, respectively. Future work will need to unpick the components of these interventions to help isolate active ingredients and increase optimization.}, added-at = {2023-04-03T06:45:40.000+0200}, author = {Garcia-Toro, M. and Aguilar-Latorre, A. and Garcia, A. and Navarro-Guzmán, C. and Gervilla, E. and Seguí, A. and Gazquez, F. and Marino, J. A. and Gomez-Juanes, R. and Serrano-Ripoll, M. J. and Oliván-Blázquez, B. and Garcia-Campayo, J. and Maloney, S. and Montero-Marin, J.}, biburl = {https://www.bibsonomy.org/bibtex/282defb8f094b6e60f9253b411cc2b5b3/nachoricci}, doi = {10.3389/fpsyg.2023.1008891}, interhash = {eb87d26354ddf681d2f936ece786f5e7}, intrahash = {82defb8f094b6e60f9253b411cc2b5b3}, issn = {1664-1078 (Print) 1664-1078}, journal = {Front Psychol}, keywords = {grapp-caib}, pages = 1008891, timestamp = {2023-04-03T06:45:40.000+0200}, title = {Mindfulness skills and experiential avoidance as therapeutic mechanisms for treatment-resistant depression through mindfulness-based cognitive therapy and lifestyle modification}, type = {Journal Article}, volume = 14, year = 2023 }