%0 Journal Article %1 WOS:000308855000010 %A Filho, P F Facanha %A Freire, P T C %A Sousa, G P De %A Melo, F E A %A dos Santos, A O %A Ribeiro, P R S %A Moreno, A J D %A Lima, R J C %C PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS %D 2012 %I ELSEVIER SCIENCE BV %J VIBRATIONAL SPECTROSCOPY %K Raman Thermal X-ray analysis} diffraction; sesquihydrate; spectroscopy; {Methyldopa %P 59-63 %R 10.1016/j.vibspec.2012.07.007 %T Temperature-induced phase transition in methyldopa sesquihydrate revealed via X-ray diffraction, thermal analysis and Raman spectroscopy %V 62 %X Methyldopa sesquihydrate (C10H13NO4 center dot 1.5H(2)O) is a substance used in the treatment of hypertension being one of the most widely used drugs in the world. In this work we have studied the stability of this drug as a function of temperature using four different techniques: X-ray diffraction. thermogravimetric analysis. differential scanning calorimetry and Raman spectroscopy. From the combination of these techniques we were able to infer about a set of phase transitions during the loss of water from the crystal around the temperatures of 388 K (changes only in the lattice modes) and between temperatures 393 and 423 K, when all water leaves the crystal and changes in some lattice modes and in some internal modes occur. (C) 2012 Elsevier B.V. All rights reserved.

@article{WOS:000308855000010, abstract = {Methyldopa sesquihydrate (C10H13NO4 center dot 1.5H(2)O) is a substance used in the treatment of hypertension being one of the most widely used drugs in the world. In this work we have studied the stability of this drug as a function of temperature using four different techniques: X-ray diffraction. thermogravimetric analysis. differential scanning calorimetry and Raman spectroscopy. From the combination of these techniques we were able to infer about a set of phase transitions during the loss of water from the crystal around the temperatures of 388 K (changes only in the lattice modes) and between temperatures 393 and 423 K, when all water leaves the crystal and changes in some lattice modes and in some internal modes occur. (C) 2012 Elsevier B.V. All rights reserved.}, added-at = {2022-05-23T20:00:14.000+0200}, address = {PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS}, author = {Filho, P F Facanha and Freire, P T C and Sousa, G P De and Melo, F E A and dos Santos, A O and Ribeiro, P R S and Moreno, A J D and Lima, R J C}, biburl = {https://www.bibsonomy.org/bibtex/26226b7a550469086202f507997ffc170/ppgfis_ufc_br}, doi = {10.1016/j.vibspec.2012.07.007}, interhash = {eb9b51966d44e631d953cc52a1f30433}, intrahash = {6226b7a550469086202f507997ffc170}, issn = {0924-2031}, journal = {VIBRATIONAL SPECTROSCOPY}, keywords = {Raman Thermal X-ray analysis} diffraction; sesquihydrate; spectroscopy; {Methyldopa}, pages = {59-63}, publisher = {ELSEVIER SCIENCE BV}, pubstate = {published}, timestamp = {2022-05-23T20:00:14.000+0200}, title = {Temperature-induced phase transition in methyldopa sesquihydrate revealed via X-ray diffraction, thermal analysis and Raman spectroscopy}, tppubtype = {article}, volume = 62, year = 2012 }