Abstract
The discovery of new substances with proven antimicrobial activity is
the current study goal of various researchers. Usage of synthetic
products has grown considerably in the past few years due to processing
agility, and capability of going through previous chemical modifications
in order to enhance its biological activity. Widespread careless use of
antimicrobials has made the number of resistant microorganisms rise
significantly, thus demanding more efficient drugs to fight them. One of
these synthetic candidates for this purpose is the substance
2,2-Dimethyl-5-(4H-1,2,4-triazol-4-ylaminomethylene)-1,3-dioxane-4,6-dio
ne (C9H10N4O4), aminomethylene derivative from Meldrum's acid. This
substance, alone and in association with common antibiotics, were
evaluated in vitro for antimicrobial activity, and had their minimum
inhibitory concentration (MIC) towards Staphylococcus aureus ATCC 25923,
Escherichia coli ATCC 10536 and Pseudomonas aeruginosa ATCC 15442, as
well as multiresistant strains Escherichia coli 27, Staphylococcus
aureus 358 and Pseudomonas aeruginosa 03 determined. The antimicrobial
modulation action tests of the aminoglycosides with C9H10N4O4 were
performed according to the microdilution method, and resulted in
observation of a positive synergic effect.
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