%0 Journal Article %1 somorjai:1995:ccd %A Somorjai, Ray L. %A Nikulin, Alexander E. %A Pizzi, Nic %A Jackson, Dick %A Scarth, Gordon %A Dolenko, Brion %A Gordon, Heather %A Russell, Peter %A Lean, Cynthia L. %A Delbridge, Leigh %A Mountford, Carolyn E. %A Smith, Ian C. P. %D 1995 %J Magnetic Resonance Medicine %K ANN, GEPPETTO LDA, algorithms, classification, computerised consensus diagnosis, genetic magnetic neoplasms, programming, proton resonance robust spectrum, thyroid %N 2 %P 257--263 %T Computerized Consensus Diagnosis: A Classification Strategy for the Robust Analysis of MR spectra. I. Application to 1H Spectra of Thyroid Neoplasms %U http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7707918&dopt=Abstract %V 33 %X We introduce and apply a new classification strategy we call computerized consensus diagnosis (CCD). Its purpose is to provide robust, reliable classification of biomedical data. The strategy involves the cross-validated training of several classifiers of diverse conceptual and methodological origin on the same data, and appropriately combining their outcomes. The strategy is tested on proton magnetic resonance spectra of human thyroid biopsies, which are successfully allocated to normal or carcinoma classes. We used Linear Discriminant Analysis, a Neural Net-based method, and Genetic Programming as independent classifiers on two spectral regions, and chose the median of the six classification outcomes as the consensus. This procedure yielded 100% specificity and 100% sensitivity on the training sets, and 100% specificity and 98% sensitivity on samples of known malignancy in the test sets. We discuss the necessary steps any classification approach must take to guarantee reliability, and stress the importance of fuzziness and undecidability in robust classification.

@article{somorjai:1995:ccd, abstract = {We introduce and apply a new classification strategy we call computerized consensus diagnosis (CCD). Its purpose is to provide robust, reliable classification of biomedical data. The strategy involves the cross-validated training of several classifiers of diverse conceptual and methodological origin on the same data, and appropriately combining their outcomes. The strategy is tested on proton magnetic resonance spectra of human thyroid biopsies, which are successfully allocated to normal or carcinoma classes. We used Linear Discriminant Analysis, a Neural Net-based method, and Genetic Programming as independent classifiers on two spectral regions, and chose the median of the six classification outcomes as the consensus. This procedure yielded 100% specificity and 100% sensitivity on the training sets, and 100% specificity and 98% sensitivity on samples of known malignancy in the test sets. We discuss the necessary steps any classification approach must take to guarantee reliability, and stress the importance of fuzziness and undecidability in robust classification.}, added-at = {2008-06-19T17:35:00.000+0200}, author = {Somorjai, Ray L. and Nikulin, Alexander E. and Pizzi, Nic and Jackson, Dick and Scarth, Gordon and Dolenko, Brion and Gordon, Heather and Russell, Peter and Lean, Cynthia L. and Delbridge, Leigh and Mountford, Carolyn E. and Smith, Ian C. P.}, biburl = {https://www.bibsonomy.org/bibtex/2e0b0fae87b2d52448eb46968284dd4a9/brazovayeye}, interhash = {f25e352d10273e1355cfc58f3755ad07}, intrahash = {e0b0fae87b2d52448eb46968284dd4a9}, issn = {0740-3194}, journal = {Magnetic Resonance Medicine}, keywords = {ANN, GEPPETTO LDA, algorithms, classification, computerised consensus diagnosis, genetic magnetic neoplasms, programming, proton resonance robust spectrum, thyroid}, month = {February}, notes = {PMID: 7707918 [PubMed - indexed for MEDLINE] consensus means taking 2 of 3 vote from the three different classifiers (GP, LDA and NN).}, number = 2, pages = {257--263}, timestamp = {2008-06-19T17:51:56.000+0200}, title = {Computerized Consensus Diagnosis: {A} Classification Strategy for the Robust Analysis of {MR} spectra. {I}. Application to {1H} Spectra of Thyroid Neoplasms}, url = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7707918&dopt=Abstract}, volume = 33, year = 1995 }