%0 Journal Article %1 Dhand2011 %A Dhand, Abhay %A Bayer, Arnold S. %A Pogliano, Joseph %A Yang, Soo-Jin %A Bolaris, Michael %A Nizet, Victor %A Wang, Guiquing %A Sakoulas, George %D 2011 %J Clin Infect Dis %K mrsa drugresistance drug endocarditis bacteremia %N 2 %P 158--163 %R 10.1093/cid/cir340 %T Use of antistaphylococcal beta-lactams to increase daptomycin activity in eradicating persistent bacteremia due to methicillin-resistant Staphylococcus aureus: role of enhanced daptomycin binding. %U http://dx.doi.org/10.1093/cid/cir340 %V 53 %X We used daptomycin plus antistaphylococcal β-lactams (ASBL) to clear refractory MRSA bacteremia. In vitro studies showed enhanced daptomycin bactericidal activity, increased membrane daptomycin binding, and decrease in positive surface charge induced by ASBLs against daptomycin nonsusceptible MRSA. Addition of ASBLs to daptomycin may be of benefit in refractory MRSA bacteremia. (Although the official designation is "daptomycin nonsusceptiblity," we will use the term "daptomycin-resistance" in this paper for facility of presentation.).

@article{Dhand2011, abstract = {We used daptomycin plus antistaphylococcal β-lactams (ASBL) to clear refractory MRSA bacteremia. In vitro studies showed enhanced daptomycin bactericidal activity, increased membrane daptomycin binding, and decrease in positive surface charge induced by ASBLs against daptomycin nonsusceptible MRSA. Addition of ASBLs to daptomycin may be of benefit in refractory MRSA bacteremia. (Although the official designation is "daptomycin nonsusceptiblity," we will use the term "daptomycin-resistance" in this paper for facility of presentation.).}, added-at = {2012-03-16T00:20:10.000+0100}, author = {Dhand, Abhay and Bayer, Arnold S. and Pogliano, Joseph and Yang, Soo-Jin and Bolaris, Michael and Nizet, Victor and Wang, Guiquing and Sakoulas, George}, biburl = {https://www.bibsonomy.org/bibtex/2414ffe7f496714b8b3c84652b8bf0523/aorchid}, doi = {10.1093/cid/cir340}, file = {:ID_General/ClinInfectDis.158.63.pdf:PDF}, groups = {public}, institution = {Department of Medicine, Division of Infectious Diseases, New York Medical College, Valhalla, New York 10595, USA. abhay_dhand@nymc.edu}, interhash = {f297b1d37f76565c798d92ce283d5417}, intrahash = {414ffe7f496714b8b3c84652b8bf0523}, journal = {Clin Infect Dis}, keywords = {mrsa drugresistance drug endocarditis bacteremia}, language = {eng}, medline-pst = {ppublish}, month = Jul, number = 2, pages = {158--163}, pii = {cir340}, pmid = {21690622}, timestamp = {2012-03-16T00:20:10.000+0100}, title = {Use of antistaphylococcal beta-lactams to increase daptomycin activity in eradicating persistent bacteremia due to methicillin-resistant Staphylococcus aureus: role of enhanced daptomycin binding.}, url = {http://dx.doi.org/10.1093/cid/cir340}, username = {aorchid}, volume = 53, year = 2011 }