Abstract
We review recent evidence illustrating the fundamental difference
between cytoplasmic and test tube biochemical kinetics and thermodynamics,
and showing the breakdown of the law of mass action and power-law
approximation in in vivo conditions. Simulations of biochemical reactions
in non-homogeneous media show that as a result of anomalous diffusion
and mixing of the biochemical species, reactions follow a fractal-like
kinetics. Consequently, the conventional equations for biochemical
pathways fail to describe the reactions in in vivo conditions. We
present a modification to fractal-like kinetics following the Zipf-Mandelbrot
distribution which will enable the modelling and analysis of biochemical
reactions occurring in crowded intracellular environments.
- 15142746
- algorithms,
- biochemistry,
- biological,
- biology,
- biopolymers,
- carlo
- chemical,
- complexes,
- computational
- computer
- fractals,
- gov't,
- intracellular
- kinetics,
- macromolecular
- metabolism,
- method,
- models,
- monte
- multienzyme
- non-u.s.
- processes,
- research
- simulation,
- space,
- statistical,
- stochastic
- substances,
- support,
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