%0 Journal Article %1 Durand-Martel2010 %A Durand-Martel, Pascali %A Tremblay, Dominic %A Brodeur, Catherine %A Paquet, Nancy %D 2010 %J Can J Neurol Sci %K Autopsy methods;Brain diagnosticuse;Humans;Positron-EmissionTomography Factual pathology/radionuclideimaging;FluorodeoxyglucoseF18 methods;Radiopharmaceuticals radionuclideimaging;Databases diagnosticuse;imageriechus statistics/&/numericaldata;Dementia %N 3 %P 336--342 %T Autopsy as gold standard in FDG-PET studies in dementia. %V 37 %X Positron emission tomography (PET) imaging with F18-fluorodeoxyglucose (FDG) is increasingly used as an adjunct to clinical evaluation in the diagnosis of dementia. Considering that most FDG-PET studies in dementia use clinical diagnosis as gold standard and that clinical diagnosis is approximately 80\% sensitive or accurate, we aim to review the evidence-based data on the diagnostic accuracy of brain FDG-PET in dementia when cerebral autopsy is used as gold standard. We searched the PubMed and Medline databases for dementia-related articles that correlate histopathological diagnosis at autopsy with FDG-PET imaging and found 47 articles among which there were only 5 studies of 20 patients or more. We were able to conclude that sensitivity and specificity of FDG-PET for Alzheimer's disease are good, but more studies using histopathological diagnosis at autopsy as gold standard are needed in order to evaluate what FDG-PET truly adds to premortem diagnostic accuracy in dementia.

@article{Durand-Martel2010, abstract = {Positron emission tomography (PET) imaging with F18-fluorodeoxyglucose (FDG) is increasingly used as an adjunct to clinical evaluation in the diagnosis of dementia. Considering that most FDG-PET studies in dementia use clinical diagnosis as gold standard and that clinical diagnosis is approximately 80\% sensitive or accurate, we aim to review the evidence-based data on the diagnostic accuracy of brain FDG-PET in dementia when cerebral autopsy is used as gold standard. We searched the PubMed and Medline databases for dementia-related articles that correlate histopathological diagnosis at autopsy with FDG-PET imaging and found 47 articles among which there were only 5 studies of 20 patients or more. We were able to conclude that sensitivity and specificity of FDG-PET for Alzheimer's disease are good, but more studies using histopathological diagnosis at autopsy as gold standard are needed in order to evaluate what FDG-PET truly adds to premortem diagnostic accuracy in dementia.}, added-at = {2011-02-17T17:51:42.000+0100}, author = {Durand-Martel, Pascali and Tremblay, Dominic and Brodeur, Catherine and Paquet, Nancy}, biburl = {https://www.bibsonomy.org/bibtex/281cc96264304d538882889e57b6dffdb/edimestre.chus}, institution = {Neurology Service, Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, Quebec, Canada.}, interhash = {f39e7059ac071865e49db5b57843e4f1}, intrahash = {81cc96264304d538882889e57b6dffdb}, journal = {Can J Neurol Sci}, keywords = {Autopsy methods;Brain diagnosticuse;Humans;Positron-EmissionTomography Factual pathology/radionuclideimaging;FluorodeoxyglucoseF18 methods;Radiopharmaceuticals radionuclideimaging;Databases diagnosticuse;imageriechus statistics/&/numericaldata;Dementia}, language = {eng}, medline-pst = {ppublish}, month = May, number = 3, pages = {336--342}, pmid = {20481267}, timestamp = {2011-03-11T10:08:15.000+0100}, title = {Autopsy as gold standard in FDG-PET studies in dementia.}, volume = 37, year = 2010 }