%0 Journal Article %1 Jahns2006 %A Jahns, R. %A Boivin, V. %A Lohse, M. J. %D 2006 %J Int J Cardiol %K *Autoimmunity/drug Adrenergic Animals Autoantibodies/immunology Autoantigens/immunology Autoimmune Cardiomyopathy, Contraction/immunology Dilated/drug Diseases/*complications/drug Humans Myocardial Rats beta-1/drug beta-Antagonists/therapeutic effects effects/*immunology therapy/*immunology/physiopathology therapy/physiopathology use Receptor %N 1 %P 7-14 %T Beta 1-adrenergic receptor-directed autoimmunity as a cause of dilated cardiomyopathy in rats %U http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16872696 %V 112 %X Progressive cardiac dilatation and pump failure of unknown etiology has been termed idiopathic dilated cardiomyopathy (DCM). During recent years a large body of data has accumulated indicating that functionally active antibodies or autoantibodies being able to recognize and to stimulate the cardiac beta(1)-adrenergic receptor (anti-beta(1)-AR) may play an important role in the initiation and/or clinical course of DCM. Recent experiments in rats even point towards a cause-and-effect relation between stimulatory anti-beta(1)-AR antibodies and DCM. Immunization of rats against the second extracellular loop of the human beta(1)-adrenergic receptor (100% sequence-identity between human and rat) resulted in both development of stimulatory anti-beta(1)-AR antibodies and development of progressive cardiac dilatation and dysfunction. Isogenic transfer of stimulatory anti-beta(1)-AR from cardiomyopathic into healthy inbred animals reproduced the disease, hence providing conclusive proof for a beta(1)-receptor-directed autoimmune attack as a possible cause of cardiomyopathy. This kind of cardiomyopathy is now referred to as anti-beta(1)-AR-induced dilated immune-cardiomyopathy (DiCM). The following article reviews recent evidence obtained from experimental animal-models implying a significant role of the cardiac beta(1)-adrenergic receptor as a pathophysiologically and clinically relevant autoantigen also in human DCM.

@article{Jahns2006, abstract = {Progressive cardiac dilatation and pump failure of unknown etiology has been termed idiopathic dilated cardiomyopathy (DCM). During recent years a large body of data has accumulated indicating that functionally active antibodies or autoantibodies being able to recognize and to stimulate the cardiac beta(1)-adrenergic receptor (anti-beta(1)-AR) may play an important role in the initiation and/or clinical course of DCM. Recent experiments in rats even point towards a cause-and-effect relation between stimulatory anti-beta(1)-AR antibodies and DCM. Immunization of rats against the second extracellular loop of the human beta(1)-adrenergic receptor (100% sequence-identity between human and rat) resulted in both development of stimulatory anti-beta(1)-AR antibodies and development of progressive cardiac dilatation and dysfunction. Isogenic transfer of stimulatory anti-beta(1)-AR from cardiomyopathic into healthy inbred animals reproduced the disease, hence providing conclusive proof for a beta(1)-receptor-directed autoimmune attack as a possible cause of cardiomyopathy. This kind of cardiomyopathy is now referred to as anti-beta(1)-AR-induced dilated immune-cardiomyopathy (DiCM). The following article reviews recent evidence obtained from experimental animal-models implying a significant role of the cardiac beta(1)-adrenergic receptor as a pathophysiologically and clinically relevant autoantigen also in human DCM.}, added-at = {2010-12-14T18:12:02.000+0100}, author = {Jahns, R. and Boivin, V. and Lohse, M. J.}, biburl = {https://www.bibsonomy.org/bibtex/291e2a60459f9a0e89d8b631f7e5abca3/pharmawuerz}, endnotereftype = {Journal Article}, interhash = {f63dbe055b2cf0e49a928e320bb046cd}, intrahash = {91e2a60459f9a0e89d8b631f7e5abca3}, issn = {0167-5273 (Print) 0167-5273 (Linking)}, journal = {Int J Cardiol}, keywords = {*Autoimmunity/drug Adrenergic Animals Autoantibodies/immunology Autoantigens/immunology Autoimmune Cardiomyopathy, Contraction/immunology Dilated/drug Diseases/*complications/drug Humans Myocardial Rats beta-1/drug beta-Antagonists/therapeutic effects effects/*immunology therapy/*immunology/physiopathology therapy/physiopathology use Receptor}, month = {Sep 10}, note = {Jahns, Roland Boivin, Valerie Lohse, Martin J Research Support, Non-U.S. Gov't Review Ireland International journal of cardiology Int J Cardiol. 2006 Sep 10;112(1):7-14. Epub 2006 Jul 26.}, number = 1, pages = {7-14}, shorttitle = {Beta 1-adrenergic receptor-directed autoimmunity as a cause of dilated cardiomyopathy in rats}, timestamp = {2010-12-14T18:22:40.000+0100}, title = {Beta 1-adrenergic receptor-directed autoimmunity as a cause of dilated cardiomyopathy in rats}, url = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16872696}, volume = 112, year = 2006 }