Present work considers the parametric optimization of CNC MAX MILL machining for Mild Steel (EN18) with Cemented Carbide as cutting tool under constant flow of coolant. The machining cutting parameters (cutting speed, feed rate and depth of cut) optimized to evaluate high material removal rate and minimum surface roughness. Response surface method interpreted the experiment data with the help of Design of experiment. Analysis of variance (ANOVA) shows the different parameters which provide the significant impact on the values of surface roughness and material removal rate. The optimum solution of Material Removal Rate (MRR) and Roughness (SR) can be found at the cutting speed of 4186 rpm, feed rate of 1831 mm/min. and depth of cut of 0.60 mm.