These results suggest that neuronal and membrane functions are important for rapid auditory processing. This investigation provides a first link between the electrophysiology, as recorded by magnetoencephalography, and the neurochemistry, as assessed by proton magnetic resonance spectroscopy, of the auditory cortex.
A laser fiber was delivered via a catheter inserted through a perineal template and guided to the target with MRI. The tissue temperature was monitored during laser ablation by MRI thermometry. Accumulated thermal damage was calculated in real time. Immediate post-treatment contrast-enhanced MRI confirmed devascularization of the target. No adverse events were noted. MRI-guided focal laser therapy of low-risk PCa is feasible and may offer a good balance between cancer control and side effects.
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3271-9(July 2002)Volpini, Rosaria Costanzi, Stefano Lambertucci, Catia Taffi, Sara
Vittori, Sauro Klotz, Karl-Norbert Cristalli, Gloria Research Support,
Non-U.S. Gov't United States Journal of medicinal chemistry J Med
Chem. 2002 Jul 18;45(15):3271-9..
P. Conti, C. Dallanoce, M. Amici, C. Micheli, and K. Klotz. Bioorg Med Chem, 6 (4):
401-8(April 1998)Conti, P Dallanoce, C De Amici, M De Micheli, C Klotz, K N Research
Support, Non-U.S. Gov't England Bioorganic & medicinal chemistry
Bioorg Med Chem. 1998 Apr;6(4):401-8..
C. Muller, J. Sandoval-Ramirez, U. Schobert, U. Geis, W. Frobenius, and K. Klotz. Bioorg Med Chem, 6 (6):
707-19(June 1998)Muller, C E Sandoval-Ramirez, J Schobert, U Geis, U Frobenius, W
Klotz, K N England Bioorganic & medicinal chemistry Bioorg Med Chem.
1998 Jun;6(6):707-19..