Statins have pleiotropic effects: anti-inflammatory, immunomodulatory, antithrombotic, and vascular activity, & may improve left ventricular myocardial function & left ventricular diastolic function by increasing vascular elasticity.
F. Wiesmann, J. Ruff, S. Engelhardt, L. Hein, C. Dienesch, A. Leupold, R. Illinger, A. Frydrychowicz, K. Hiller, E. Rommel and 3 other author(s). Circ Res, 88 (6):
563-9(March 2001)Wiesmann, F Ruff, J Engelhardt, S Hein, L Dienesch, C Leupold, A
Illinger, R Frydrychowicz, A Hiller, K H Rommel, E Haase, A Lohse,
M J Neubauer, S Research Support, Non-U.S. Gov't United States Circulation
research Circ Res. 2001 Mar 30;88(6):563-9..
C. Semsarian, I. Ahmad, M. Giewat, D. Georgakopoulos, J. Schmitt, B. McConnell, S. Reiken, U. Mende, A. Marks, D. Kass and 2 other author(s). J Clin Invest, 109 (8):
1013-20(April 2002)Semsarian, Christopher Ahmad, Imran Giewat, Michael Georgakopoulos,
Dimitrios Schmitt, Joachim P McConnell, Bradley K Reiken, Steven
Mende, Ulrike Marks, Andrew R Kass, David A Seidman, Christine E
Seidman, J G Research Support, Non-U.S. Gov't Research Support, U.S.
Gov't, P.H.S. United States The Journal of clinical investigation
J Clin Invest. 2002 Apr;109(8):1013-20..
J. Schmitt, J. Schroder, H. Schunkert, D. Birnbaum, and H. Aebert. Ann Thorac Surg, 73 (4):
1229-35(April 2002)Schmitt, Joachim P Schroder, Josef Schunkert, Heribert Birnbaum,
Dietrich E Aebert, Hermann United States The Annals of thoracic surgery
Ann Thorac Surg. 2002 Apr;73(4):1229-35..
B. Palmer, D. Fishbaugher, J. Schmitt, Y. Wang, N. Alpert, C. Seidman, J. Seidman, P. VanBuren, and D. Maughan. Am J Physiol Heart Circ Physiol, 287 (1):
H91-9(July 2004)Palmer, Bradley M Fishbaugher, David E Schmitt, Joachim P Wang, Yuan
Alpert, Norman R Seidman, Christine E Seidman, J G VanBuren, Peter
Maughan, David W HL-59408-3/HL/NHLBI NIH HHS/United States In Vitro
Research Support, U.S. Gov't, P.H.S. United States American journal
of physiology. Heart and circulatory physiology Am J Physiol Heart
Circ Physiol. 2004 Jul;287(1):H91-9. Epub 2004 Mar 4..
S. Neubauer, M. Frank, K. Hu, H. Remkes, A. Laser, M. Horn, G. Ertl, and M. Lohse. J Mol Cell Cardiol, 30 (4):
803-10(April 1998)Neubauer, S Frank, M Hu, K Remkes, H Laser, A Horn, M Ertl, G Lohse,
M J Research Support, Non-U.S. Gov't England Journal of molecular
and cellular cardiology J Mol Cell Cardiol. 1998 Apr;30(4):803-10..