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1Curing the Incurable: Cancer - by Adam Gaertner
https://veryvirology.substack.com/p/curing-the-incurable-cancer
a year ago by @fordham1
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1MedinCell announces positive results for the SAIVE clinical study in prevention of Covid-19 infection in a contact-based population - MEDINCELL
https://www.medincell.com/en/2023/01/05/medincell-announces-positive-results-for-the-saive-clinical-study-in-prevention-of-covid-19-infection-in-a-contact-based-population/
a year ago by @fordham1
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1The Miracle Not-Heard Around The World: The Success of Uttar Pradesh - Part 1
https://pierrekory.substack.com/p/the-miracle-not-heard-around-the
2 years ago by @fordham1
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1Whoops! The TOGETHER Trial actually showed that ivermectin worked.
https://stevekirsch.substack.com/p/did-the-together-study-show-that?s=r
2 years ago by @fordham1
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1The False, Sinister, and Duplicitous Statements of the TOGETHER Ivermectin Trial Investigators
https://pierrekory.substack.com/p/the-false-sinister-and-duplicitous
2 years ago by @fordham1
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1TOGETHER Trial - Index of Articles & Podcasts
I’ve written and said a lot about the TOGETHER trial, in an effort to share the knowledge I’ve been gathering. This page contains links to articles & podcasts I have made, in this Substack and elsewhere. Before we dive in, if you’re looking for a good starting point, this is probably it:
2 years ago by @fordham1
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1Misconceptions about ivermectin dosing - by Joomi
https://joomi.substack.com/p/misconceptions-about-ivermectin-dosing?s=w
2 years ago by @fordham1
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1Pfizermectin and molnupiravir
https://randombio.com/pfizermectin.html
3 years ago by @fordham1
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1Pfizer’s Novel COVID-19 Oral Antiviral Treatment Candidate Reduced Risk of Hospitalization or Death by 89% in Interim Analysis of Phase 2/3 EPIC-HR Study | Pfizer
https://www.pfizer.com/news/press-release/press-release-detail/pfizers-novel-covid-19-oral-antiviral-treatment-candidate
3 years ago by @fordham1
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1Ivermectin: Much More Than You Wanted To Know - Astral Codex Ten
Ivermectin
3 years ago by @bshanks
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1Zinc Ionophore (Clioquinol) Inhibition of Human ZIP1-Deficient Prostate Tumor Growth in the Mouse Ectopic Xenograft Model: A Zinc Approach for the Efficacious Treatment of Prostate Cancer
R. Franklin. (2016)
7 hours ago by @fordham1
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2The multitargeted drug ivermectin: from an antiparasitic agent to a repositioned cancer drug
M. Juarez, A. Schcolnik-Cabrera, and A. Dueñas-Gonzalez. American Journal of Cancer Research, 8 (2): 317-331 (2018)
7 hours ago by @fordham1
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1Targeting tumor hypoxia and mitochondrial metabolism with anti-parasitic drugs to improve radiation response in high-grade gliomas
F. Mudassar, H. Shen, G. O'Neill, and E. Hau. Journal of Experimental & Clinical Cancer Research, 39 (1): 208 (Oct 7, 2020)
7 hours ago by @fordham1
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1Selective Inhibition of SIN3 Corepressor with Avermectins as a Novel Therapeutic Strategy in Triple-Negative Breast Cancer
Y. Kwon, K. Petrie, B. Leibovitch, L. Zeng, M. Mezei, L. Howell, V. Gil, R. Christova, N. Bansal, S. Yang and 11 other author(s). Molecular Cancer Therapeutics, 14 (8): 1824–1836 (August 2015)
7 hours ago by @fordham1
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cancer
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1Repurposing Ivermectin to augment chemotherapy’s efficacy in osteosarcoma
B. Hu, H. Tan, L. Yu, Q. Liao, and W. Guo. Human and Experimental Toxicology, (2022)
7 hours ago by @fordham1
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2Modulation of P2X4/P2X7/Pannexin-1 sensitivity to extracellular ATP via Ivermectin induces a non-apoptotic and inflammatory form of cancer cell death
D. Draganov, S. Gopalakrishna-Pillai, Y. Chen, N. Zuckerman, S. Moeller, C. Wang, D. Ann, and P. Lee. Scientific Reports, 5 (1): 16222 (Nov 10, 2015)
8 hours ago by @fordham1
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2Modulation of P2X4/P2X7/Pannexin-1 sensitivity to extracellular ATP via Ivermectin induces a non-apoptotic and inflammatory form of cancer cell death
D. Draganov, S. Gopalakrishna-Pillai, Y. Chen, N. Zuckerman, S. Moeller, C. Wang, D. Ann, and P. Lee. Scientific Reports, 5 (1): 16222 (Nov 10, 2015)
8 hours ago by @ivermectin
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2Optimization of Extracellular signal-regulated kinase 5 (ERK5) targeting in melanoma
Z. Lombardi. Università di Siena, Doctorate in Genetics Oncology and Clinical Medicine, (March 2023)
8 hours ago by @fordham1
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2Optimization of Extracellular signal-regulated kinase 5 (ERK5) targeting in melanoma
Z. Lombardi. Università di Siena, Doctorate in Genetics Oncology and Clinical Medicine, (March 2023)
8 hours ago by @ivermectin
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1Novel selective inhibitors of macropinocytosis-dependent growth in pancreatic ductal carcinoma
S. Brambillasca, M. Cera, A. Andronache, S. Dey, G. Fagá, D. Fancelli, E. Frittoli, M. Pasi, M. Robusto, M. Varasi and 2 other author(s). Biomedicine and Pharmacotherapy, (August 2024)
8 hours ago by @fordham1
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1Ivermectin induces autophagy-mediated cell death through the AKT/mTOR signaling pathway in glioma cells
J. Liu, H. Liang, C. Chen, X. Wang, F. Qu, H. Wang, K. Yang, Q. Wang, N. Zhao, J. Meng and 1 other author(s). Bioscience Reports, (December 2019)
8 hours ago by @fordham1
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cancer
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1Macrocyclic Lactones Block Melanoma Growth, Metastases Development and Potentiate Activity of Anti–BRAF V600 Inhibitors
F. Gallardo, I. Teiti, P. Rochaix, E. Demilly, D. Jullien, B. Mariamé, and A. Tilkin-Mariamé. Clinical Skin Cancer, 1 (1): 4-14.e3 (January 2016)
8 hours ago by @fordham1
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4Ivermectin suppresses tumour growth and metastasis through degradation of PAK1 in oesophageal squamous cell carcinoma
L. Chen, S. Bi, Q. Wei, Z. Zhao, C. Wang, and S. Xie. Journal of Cellular and Molecular Medicine, 24 (9): 5387–5401 (March 2020)
8 hours ago by @ivermectin
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4Ivermectin suppresses tumour growth and metastasis through degradation of PAK1 in oesophageal squamous cell carcinoma
L. Chen, S. Bi, Q. Wei, Z. Zhao, C. Wang, and S. Xie. Journal of Cellular and Molecular Medicine, 24 (9): 5387–5401 (March 2020)
8 hours ago by @fordham1
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1Ivermectin inhibits tumor metastasis by regulating the Wnt/β-catenin/integrin β1/FAK signaling pathway
L. Jiang, Y. Sun, X. Song, Y. Sun, W. Yang, J. Li, and Y. Wu. American journal of cancer research, 12 (10): 4502--4519 (October 2022)
8 hours ago by @fordham1
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1Ivermectin inhibits the growth of glioma cells by inducing cell cycle arrest and apoptosis in vitro and in vivo
D. Song, H. Liang, B. Qu, Y. Li, J. Liu, Y. Zhang, L. Li, L. Hu, X. Zhang, and A. Gao. Journal of Cellular Biochemistry, (2018)
10 hours ago by @fordham1
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2Ivermectin Induces Cytostatic Autophagy by Blocking the PAK1/Akt Axis in Breast Cancer
Q. Dou, H. Chen, K. Wang, K. Yuan, Y. Lei, K. Li, J. Lan, Y. Chen, Z. Huang, N. Xie and 5 other author(s). Cancer Research, 76 (15): 4457–4469 (July 2016)
10 hours ago by @fordham1
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2Ivermectin Induces Cytostatic Autophagy by Blocking the PAK1/Akt Axis in Breast Cancer
Q. Dou, H. Chen, K. Wang, K. Yuan, Y. Lei, K. Li, J. Lan, Y. Chen, Z. Huang, N. Xie and 5 other author(s). Cancer Research, 76 (15): 4457–4469 (July 2016)
10 hours ago by @ivermectin
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2Ivermectin inactivates the kinase PAK1 and blocks the PAK1-dependent growth of human ovarian cancer and NF2 tumour cell lines
H. Hashimoto, S. Messerli, T. Sudo, and H. Maruta. Drug Discoveries and Therapeutics, 3 (6): 243-246 (2009)
10 hours ago by @fordham1
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2Ivermectin inactivates the kinase PAK1 and blocks the PAK1-dependent growth of human ovarian cancer and NF2 tumour cell lines
H. Hashimoto, S. Messerli, T. Sudo, and H. Maruta. Drug Discoveries and Therapeutics, 3 (6): 243-246 (2009)
10 hours ago by @ivermectin
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1Ivermectin has New Application in Inhibiting Colorectal Cancer Cell Growth
S. Zhou, H. Wu, W. Ning, X. Wu, X. Xu, Y. Ma, X. Li, J. Hu, C. Wang, and J. Wang. Frontiers in Pharmacolocgy, (2021)
10 hours ago by @fordham1
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2Ivermectin converts cold tumors hot and synergizes with immune checkpoint blockade for treatment of breast cancer
D. Draganov, Z. Han, A. Rana, N. Bennett, D. Irvine, and P. Lee. npj Breast Cancer, 7 (1): 22 (Mar 2, 2021)
10 hours ago by @fordham1
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2Ivermectin converts cold tumors hot and synergizes with immune checkpoint blockade for treatment of breast cancer
D. Draganov, Z. Han, A. Rana, N. Bennett, D. Irvine, and P. Lee. npj Breast Cancer, 7 (1): 22 (Mar 2, 2021)
10 hours ago by @ivermectin
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2Ivermectin and Cancer, it has at least 15 anti-cancer mechanisms of action
W. Makis. Substack - Covid Intel, (2024)
10 hours ago by @fordham1
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2Ivermectin and Cancer, it has at least 15 anti-cancer mechanisms of action
W. Makis. Substack - Covid Intel, (2024)
10 hours ago by @ivermectin
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2Ivermectin and Cancer Part 2 - Treating Turbo Cancer
W. Makis. Substack - Covid-Intel, (2024)
10 hours ago by @fordham1
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2Ivermectin and Cancer Part 2 - Treating Turbo Cancer
W. Makis. Substack - Covid-Intel, (2024)
10 hours ago by @ivermectin
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1Ivermectin as an inhibitor of cancer stem‑like cells
G. Dominguez‑Gomez, A. Chavez‑Blanco, J. Medina‑Franco, F. Saldivar‑Gonzalez, Y. Flores‑Torrontegui, M. Juarez, J. Díaz‑Chávez, A. Gonzalez‑Fierro, and A. Dueñas‑González. Molecular Medicine Reports, (December 2017)
2 days ago by @fordham1
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1Inhaled Ivermectin-Loaded Lipid Polymer Hybrid Nanoparticles: Development and Characterization
S. Kassaee, G. Ayoko, D. Richard, T. Wang, and N. Islam. Pharmaceutics, (2024)
2 days ago by @fordham1
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cancer
ivermectin
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1Importin subunit beta‐1 mediates ERK5 nuclear translocation, and its inhibition synergizes with ERK5 kinase inhibitors in reducing cancer cell proliferation
Z. Lombardi, L. Gardini, A. Kashchuk, A. Menconi, M. Lulli, I. Tusa, A. Tubita, L. Maresca, B. Stecca, M. Capitanio and 1 other author(s). Molecular Oncology, (July 2024)
2 days ago by @fordham1
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ivermectin
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1Fenbendazole Exhibits Differential Anticancer Effects In Vitro and In Vivo in Models of Mouse Lymphoma
H. Jung, S. Kim, and H. Joo. Current Issues in Molecular Biology, 45 (11): 8925--8938 (2023)
2 days ago by @fordham1
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cancer
ivermectin
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1The river blindness drug Ivermectin and related macrocyclic lactones inhibit WNT-TCF pathway responses in human cancer
A. Melotti, C. Mas, M. Kuciak, A. Lorente‐Trigos, I. Borges, and A. Ruiz i Altaba. EMBO Molecular Medicine, 6 (10): 1263–1278 (August 2014)
2 days ago by @fordham1
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1Antitumor effects of ivermectin at clinically feasible concentrations support its clinical development as a repositioned cancer drug
M. Juarez, A. Schcolnik-Cabrera, G. Dominguez-Gomez, A. Chavez-Blanco, J. Diaz-Chavez, and A. Duenas-Gonzalez. Cancer Chemotherapy and Pharmacology, 85 (6): 1153--1163 (Jun 1, 2020)
2 days ago by @fordham1
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1Antitumor effect of avermectins
V. Drinyaev, V. Mosin, E. Kruglyak, T. Novik, T. Sterlina, N. Ermakova, L. Kublik, M. Levitman, V. Shaposhnikova, and Y. Korystov. European Journal of Pharmacology, 501 (1–3): 19–23 (October 2004)
2 days ago by @fordham1
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1Antibiotic ivermectin preferentially targets renal cancer through inducing mitochondrial dysfunction and oxidative damage
M. Zhu, Y. Li, and Z. Zhou. Biochemical and Biophysical Research Communications, 492 (3): 373–378 (October 2017)
2 days ago by @fordham1
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cancer
ivermectin
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1Anti-parasite drug ivermectin can suppress ovarian cancer by regulating lncRNA-EIF4A3-mRNA axes
N. Li, and X. Zhan. EPMA Journal, 11 (2): 289--309 (Jun 1, 2020)
2 days ago by @fordham1
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cancer
ivermectin
cancerivermectin
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1Back to the Basics of SARS-CoV-2 Biochemistry: Microvascular Occlusive Glycan Bindings Govern Its Morbidities and Inform Therapeutic Responses
D. Scheim, P. Parry, D. Rabbolini, C. Aldous, M. Yagisawa, R. Clancy, T. Borody, and W. Hoy. Viruses, (2024)
5 months ago by @fordham1
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ivermectin
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2The selective effect of Ivermectin on different human coronaviruses; in-vitro study
A. Shahin, N. Atari, T. Meningher, O. Erster, D. Avni, E. Schwartz, and M. Mandelboim. Research Square, (April 2024)
5 months ago by @fordham1
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2The selective effect of Ivermectin on different human coronaviruses; in-vitro study
A. Shahin, N. Atari, T. Meningher, O. Erster, D. Avni, E. Schwartz, and M. Mandelboim. Research Gate, (April 2024)
5 months ago by @fordham1
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ivermectin
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1Global trends in clinical trials of ivermectin for COVID-19—Part 2
M. Yagisawa, P. Foster, H. Hanaki, and S. Ōmura. Japanese Journal of Antibiotics, 77 (1): 45--92 (March 2024)
6 months ago by @fordham1
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covid-19
ivermectin
clinical_trialcovid-19ivermectin
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1SARS-CoV-2 Omicron is an immune escape variant with an altered cell entry pathway
B. Willett, J. Grove, O. MacLean, C. Wilkie, G. De Lorenzo, W. Furnon, D. Cantoni, S. Scott, N. Logan, S. Ashraf and 290 other author(s). Nature Microbiology, 7 (8): 1161--1179 (Aug 1, 2022)
6 months ago by @fordham1
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ivermectin
omicron
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1Gene signatures to therapeutics: Assessing the potential of ivermectin against t(4;14) multiple myeloma
Y. Song, H. Zhang, X. Song, J. Geng, H. Li, L. Zhang, B. Yang, and X. Lu. World Journal of Clinical Oncology, 15 (1): 115–129 (January 2024)
6 months ago by @fordham1
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ivermectin
myeloma
ivermectinmyeloma
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1Combinations of ivermectin with proteasome inhibitors induce synergistic lethality in multiple myeloma
H. Luo, Y. Feng, F. Wang, Z. Lin, J. Huang, Q. Li, X. Wang, X. Liu, X. Zhai, Q. Gao and 6 other author(s). Cancer Letters, (2023)
6 months ago by @fordham1
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myeloma
ivermectinmyeloma
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1Ivermectin for COVID-19 in adults in the community (PRINCIPLE): an open, randomised, controlled, adaptive platform trial of short- and longer-term outcomes
G. Hayward, L. Yu, P. Little, O. Gbinigie, M. Shanyinde, V. Harris, J. Dorward, B. Saville, N. Berry, P. Evans and 15 other author(s). Journal of Infection, (2024)
7 months ago by @fordham1
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ivermectin
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1Computational Prediction of the Interaction of Ivermectin with Fibrinogen
P. Vottero, S. Tavernini, A. Santin, D. Scheim, J. Tuszynski, and M. Aminpour. International Journal of Molecular Sciences, 24 (14): 11449 (July 2023)
10 months ago by @fordham1
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fribrinogen
ivermectin
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1Sialylated Glycan Bindings from SARS-CoV-2 Spike Protein to Blood and Endothelial Cells Govern the Severe Morbidities of COVID-19
D. Scheim, P. Vottero, A. Santin, and A. Hirsh. International Journal of Molecular Sciences, 24 (23): 17039 (December 2023)
10 months ago by @fordham1
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haemagglutination
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covid-19haemagglutinationivermectin
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1Integrated analysis reveals FOXA1 and Ku70/Ku80 as targets of ivermectin in prostate cancer.
S. Lv, Z. Wu, M. Luo, Y. Zhang, J. Zhang, L. Pascal, Z. Wang, and Q. Wei. Cell Death and Disease, (2022)
12 months ago by @fordham1
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cancer
ivermectin
cancerivermectin
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1Ivermectin's Role in the Prevention of COVID-19: A Systematic Review and Meta-Analysis.
G. Hu, C. Liang, P. Lin, and C. Lin. Journal of Clinical Pharmacology, (2023)
a year ago by @fordham1
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ivermectin
prophylaxis
covid-19ivermectinprophylaxis
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1Use of Ivermectin as a Potential Chemoprophylaxis for COVID-19 in Egypt: A Randomised Clinical Trial
W. Shoumann, A. Hegazy, R. Nafae, M. Ragab, S. Samra, D. Ibrahim, T. Al-Mahrouky, and A. Sileem. Journal of Clinical and Diagnostic Research, 15 (2): OC27-OC33 (February 2021)
a year ago by @fordham1
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ivermectin
prophylaxis
covid-19ivermectinprophylaxis
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1The SAIVE Trial, Post-exposure use of ivermectin in Covid-19 prevention: Efficacy and Safety Results
V. Desort-Henin, A. Kostova, E. Babiker, A. Caramel, and R. Malamut. Medincell Poster, (April 2023)
a year ago by @fordham1
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ivermectin
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1Ivermectin, a potential anticancer drug derived from an antiparasitic drug
M. Tang, X. Hu, Y. Wang, X. Yao, W. Zhang, C. Yu, F. Cheng, J. Li, and Q. Fang. Pharmacological Research, (2021)
a year ago by @fordham1
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cancer
ivermectin
cancerivermectin
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1COVID-19 Excess Deaths in Peru's 25 States in 2020: Nationwide Trends, Confounding Factors, and Correlations With the Extent of Ivermectin Treatment by State
J. Chamie, J. Hibberd, and D. Scheim. Cureus, (August 2023)
a year ago by @fordham1
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Peru
covid-19
ivermectin
Perucovid-19ivermectin
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1Successful management of poisoning with ivermectin (Mectizan) in the Obala health district (Centre Region, Cameroon): a case report.
C. Donfo-Azafack, H. Nana-Djeunga, G. Wafeu-Sadeu, R. Dongmo-Yemele, and J. Kamgno. Journal of Medical Case Reports, (2023)
a year ago by @fordham1
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Mectizan
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poisoning
Mectizanivermectinpoisoning
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1Prophylactic administration of ivermectin attenuates SARS-CoV-2 induced disease in a Syrian Hamster Model.
T. Uematsu, T. Takano, H. Matsui, N. Kobayashi, S. Ōmura, and H. Hanaki. Journal of Antibiotics, (2023)
a year ago by @fordham1
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1When Characteristics of Clinical Trials Require Per-Protocol as Well as Intention-to-Treat Outcomes to Draw Reliable Conclusions: Three Examples
D. Scheim, C. Aldous, B. Osimani, E. Fordham, and W. Hoy. Journal of Clinical Medicine, 12 (11): 3625 (May 2023)
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1Strategies for the Management of Spike Protein-Related Pathology
M. Halma, C. Plothe, P. Marik, and T. Lawrie. Microorganisms, 11 (5): 1308 (May 2023)
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1Interrogation of Streptomyces avermitilis for efficient production of avermectins
J. Chen, M. Liu, X. Liu, J. Miao, C. Fu, H. Gao, R. Müller, Q. Zhang, and L. Zhang. Synthetic and Systems Biotechnology, 1 (1): 7-16 (2016)
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1Ivermectin is associated with increase in SPO2 in hypoxemic SARS-Cov-2 patients: pharmacodynamic profile and correlates.
olufemi Emmanuel Babalola, A. Ajayi, T. Yunusa, Y. Ndanusa, J. Ogedengbe, and O. Ogu. Research Square, (April 2022)
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1Misinterpretation of statistical nonsignificance as a sign of potential bias: Hydroxychloroquine as a case study
K. Hagen. Accountability in Research, DOI: 10.1080/08989621.2022.2155517, (2022)
2 years ago by @fordham1
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1SARS-CoV-2 Spike Protein Induces Hemagglutination: Implications for COVID-19 Morbidities and Therapeutics and for Vaccine Adverse Effects
C. Boschi, D. Scheim, A. Bancod, M. Militello, M. Bideau, P. Colson, J. Fantini, and B. Scola. International Journal of Molecular Sciences, 23 (24): 15480 (December 2022)
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1SARS-CoV-2 Spike Protein Induces Hemagglutination: Implications for COVID-19 Morbidities and Therapeutics and for Vaccine Adverse Effects
C. Boschi, D. Scheim, A. Bancod, M. Millitello, M. Bideau, P. Colson, J. Fantini, and B. Scola. bioRxiv, (2022)
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1Changes in SpO2 on Room Air for 34 Severe COVID-19 Patients after Ivermectin-Based Combination Treatment: 62\% Normalization within 24 Hours
J. Stone, P. Ndarukwa, D. Scheim, B. Dancis, J. Dancis, M. Gill, and C. Aldous. Biologics, 2 (3): 196--210 (August 2022)
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1Regular Use of Ivermectin as Prophylaxis for COVID-19 Led Up to a 92\% Reduction in COVID-19 Mortality Rate in a Dose-Response Manner: Results of a Prospective Observational Study of a Strictly Controlled Population of 88,012 Subjects
L. Kerr, F. Baldi, R. Lobo, W. Assagra, F. Proenca, J. Chamie, J. Hibberd, P. Kory, and F. Cadegiani. Cureus, (August 2022)
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1Possible clustering and/or drug switching confounding obscures up to 56% reduction of symptom persistence by ivermectin. Data Summary for comment posted to JAMA re: Lopez-Medina et al.
D. Wiseman, and P. Kory. OSF Preprint, (2021)
2 years ago by @fordham1
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1Regular use of ivermectin as prophylaxis for COVID-19 led up to 92% reduction in COVID-19 mortality rate in a dose-response manner: results of a prospective observational study of a strictly controlled population of 88,012 subjects among 223,128 participants
L. Kerr, F. Baldi, R. Lôbo, W. Assagra, F. Proença, J. Hibberd, P. Kory, and C. Flávio. Research Gate, (2022)
2 years ago by @fordham1
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1The effect of ivermectin on the viral load and culture viability in early treatment of non-hospitalized patients with mild COVID-19 – A double-blind, randomized placebo-controlled trial
A. Biber, G. Harmelin, D. Lev, L. Ram, A. Shaham, I. Nemet, L. Kliker, O. Erster, M. Mandelboim, and E. Schwartz. International Journal of Infectious Diseases, (2022)
2 years ago by @fordham1
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1Microbiome-Based Hypothesis on Ivermectin's Mechanism in COVID-19: Ivermectin Feeds Bifidobacteria to Boost Immunity
S. Hazan. Frontiers in Microbiology, (July 2022)
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1Re: Expression of Concern for Bryant A, Lawrie TA, Dowswell T, Fordham EJ, Mitchell S, Hill SR, Tham TC. Ivermectin for Prevention and Treatment of COVID-19 Infection. Am J Ther. 2022$\mathsemicolon$29:e232.
A. Bryant, T. Lawrie, E. Fordham, and S. Mitchell. American Journal of Therapeutics, 29 (4): 455-459 (July 2022)
2 years ago by @fordham1
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1The broad spectrum host-directed agent ivermectin as an antiviral for SARS-CoV-2 ?
D. Jans, and K. Wagstaff. Biochemical and Biophysical Research Communications, (2021)COVID-19.
2 years ago by @fordham1
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1Surgisphere II: Repeated refusals to disclose the death and hospitalization rates for the TOGETHER trial, ivermectin vs. placebo
D. Scheim, J. Dancis, and C. Aldous. OSF Preprints, (2022)
2 years ago by @fordham1
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1The drug used in Lim et al. 2022, source not specified, had <1% incidence of AEs distinctive and common for ivermectin at this study’s very high dose, 2 mg/kg
D. Scheim. OSF Preprints, (2022)
2 years ago by @fordham1
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1Ivermectin binds avidly to plasma proteins
U. Klotz, J. Ogbuokiri, and P. Okonkwo. European Journal of Clinical Pharmacology, 39 (6): 607--608 (Dec 1, 1990)
2 years ago by @fordham1
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1Effect of Ivermectin and Atorvastatin on Nuclear Localization of Importin Alpha and Drug Target Expression Profiling in Host Cells from Nasopharyngeal Swabs of SARS-CoV-2- Positive Patients
V. Segatori, J. Garona, L. Caligiuri, J. Bizzotto, R. Lavignolle, A. Toro, P. Sanchis, E. Spitzer, A. Krolewiecki, G. Gueron and 1 other author(s). Viruses, 13 (10): 2084 (October 2021)
2 years ago by @fordham1
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2In Silico Analysis of the Multi-Targeted Mode of Action of Ivermectin and Related Compounds
M. Aminpour, M. Cannariato, J. Preto, M. Safaeeardebili, A. Moracchiato, D. Doria, F. Donato, E. Zizzi, M. Deriu, D. Scheim and 2 other author(s). Computation, 10 (4): 51 (March 2022)
2 years ago by @fordham1
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1A Deadly Embrace: Hemagglutination Mediated by SARS-CoV-2 Spike Protein at Its 22 N-Glycosylation Sites, Red Blood Cell Surface Sialoglycoproteins, and Antibody
D. Scheim. International Journal of Molecular Sciences, 23 (5): 2558 (February 2022)
2 years ago by @fordham1
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1Ivermectin for prevention and treatment of COVID-19 infection: a systematic review and meta-analysis
A. Bryant, T. Lawrie, T. Dowswell, E. Fordham, S. Mitchell, S. Hill, and T. Tham. OSF preprints, (March 2021)
2 years ago by @fordham1
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2Effect of Early Treatment with Ivermectin among Patients with Covid-19
G. Reis, E. Silva, D. Silva, L. Thabane, A. Milagres, T. Ferreira, C. dos Santos, V. Campos, A. Nogueira, A. de Almeida and 17 other author(s). New England Journal of Medicine, 386 (18): 1721-1731 (05 May 2022 2022)
2 years ago by @fordham1
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1Association between Ivermectin treatment and mortality in Covid-19: A hospital-based case-control study
Ravikirti, A. Ranjan, R. Porel, K. Agarwal, S. Tahaseen, Shyama, and A. Kumar. Research Square, (April 2022)
2 years ago by @fordham1
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1Mortality and associated risk factors in patients hospitalized due to COVID-19 in a Peruvian reference hospital
A. Soto, D. Quiñones-Laveriano, J. Azañero, R. Chumpitaz, J. Claros, L. Salazar, O. Rosales, L. Nuñez, D. Roca, and A. Alcantara. PLOS ONE, 17 (3): 1-15 (March 2022)
2 years ago by @fordham1
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2Treatment with Ivermectin Is Associated with Decreased Mortality in COVID-19 Patients: Analysis of a National Federated Database
I. Efimenko, S. Nackeeran, S. Jabori, J. Gonzalez Zamora, S. Danker, and D. Singh. International Journal of Infectious Diseases, 116 (IMED Abstracts): S1--S130 (2022)
2 years ago by @fordham1
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1A comparison of Ivermectin and Non Ivermectin based regimen for covid 19 in Abuja: effects on virus clearance, Days-to-Discharge and Mortality.
Y. Thairu, O. Babalola, A. Ajayi, Y. Ndanusa, J. Ogedengbe, and O. Omede. Research Square, (February 2022)
2 years ago by @fordham1
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1Efficacy and safety of ivermectin in the treatment of mild-to-moderate COVID-19 infection: A randomized, double blind, placebo, controlled trial
A. Manomaipiboon, K. Pholtawornkulchai, S. Pupipatpab, S. Suraamornkul, J. Maneerit, W. Ruksakul, U. Phumisantiphong, and T. Trakarnvanich. Research Square, (February 2022)
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1Indomethacin Use for Mild &amp$\mathsemicolon$ Moderate hospitalised Covid-19 patients: An open label randomized clinical trial
R. Ravichandran, S. Mohan, S. Sukumaran, D. Kamaraj, S. Daivasuga, S. Ravi, S. Vijayaraghavalu, and R. Kumar. medRxiv, (July 2021)
2 years ago by @fordham1
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1A nicotinic hypothesis for Covid-19 with preventive and therapeutic implications
J. Changeux, Z. Amoura, F. Rey, and M. Miyara. Qeios, (April 2020)
2 years ago by @fordham1
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1A Retrospective Study on Pre Exposure Hydroxychloroquine and Ivermectin Prophylaxis for COVID-19 in Healthcare Workers in a Tertiary Care Hospital
D. Das, S. Bhattacharya, P. Chakrabarty, S. Saha, and N. Pal. International Journal of Health and Clinical Research, 4 (17): 66-70 (2021)
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1The lesson of ivermectin: meta-analyses based on summary data alone are inherently unreliable.
J. Lawrence, G. Meyerowitz-Katz, J. Heathers, N. Brown, and K. Sheldrick. Nature Medicine, (2021)
2 years ago by @fordham1
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1Effectiveness of ivermectin-based multidrug therapy in severely hypoxic, ambulatory COVID-19 patients
S. Hazan, S. Dave, A. Gunaratne, S. Dolai, R. Clancy, P. McCullough, and T. Borody. Future Microbiology, 17 (5): 339--350 (March 2022)
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1Combined Therapy with Ivermectin and Doxycycline can effectively alleviate the Cytokine Storm of COVID-19 Infection amid Vaccination Drive: A Narrative Review
S. Sharma, P. Bhatt, S. Asdaq, M. Alshammari, A. Alanazi, N. Alrasheedi, B. Alrashdi, S. Alyami, B. Alhazmi, P. Alam and 4 other author(s). Journal of Infection and Public Health, (2022)
2 years ago by @fordham1
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2Effect of Early Treatment with Ivermectin among Patients with Covid-19
G. Reis, E. Silva, D. Silva, L. Thabane, A. Milagres, T. Ferreira, C. dos Santos, V. Campos, A. Nogueira, A. de Almeida and 17 other author(s). New England Journal of Medicine, (30 March 2022 2022)
3 years ago by @fordham1
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2Treatment with Ivermectin Is Associated with Decreased Mortality in COVID-19 Patients: Analysis of a National Federated Database
I. Efimenko, S. Nackeeran, S. Jabori, J. Zamora, S. Danker, and D. Singh. International Journal of Infectious Diseases, (2022)
3 years ago by @fordham1
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1Factors associated with increased mortality in critically ill COVID-19 patients in a Mexican public hospital: the other faces of health system oversaturation
M. Guzmán, A. Castillo-Gonzalez, J. Gonzalez, M. Gámez, E. Enciso, I. Robles, A. D\'ıaz, C. Peña, L. Medina, V. Colin and 1 other author(s). (March 2021)
3 years ago by @fordham1
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1Re: “Commentary” by Rothrock et al. “Meta-Analyses Did Not Establish Improved Mortality With Ivermectin Use in COVID-19”
A. Bryant, T. Lawrie, E. Fordham, and S. Mitchell. American Journal of Therapeutics, (December 2021)
3 years ago by @fordham1
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1Meta-Analyses Do Not Establish Improved Mortality With Ivermectin Use in COVID-19
S. Rothrock, K. Weber, P. Giordano, and M. Barneck. American Journal of Therapeutics, 29 (1): e87--e94 (December 2021)
3 years ago by @fordham1
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1Expression of Concern for Bryant a, Lawrie TA, Dowswell T, Fordham EJ, Mitchell S, Hill SR, Tham TC. Ivermectin for Prevention and Treatment of COVID-19 Infection
P. Manu. American Journal of Therapeutics, 29 (2): e232 (February 2022)
3 years ago by @fordham1
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1Efficacy of Ivermectin Treatment on Disease Progression Among Adults With Mild to Moderate COVID-19 and Comorbidities: The I-TECH Randomized Clinical Trial.
S. Lim, C. Hor, and K. Tay. JAMA Internal Medicine, (February 2022)
3 years ago by @fordham1
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1Safety and Efficacy of a MEURI Program for the Use of High Dose Ivermectin in COVID-19 Patients
M. Mayer, A. Krolewiecki, A. Ferrero, M. Bocchio, J. Barbero, M. Miguel, A. Paladini, C. Delgado, J. Ojeda, C. Elorza and 4 other author(s). Frontiers in Public Health, (February 2022)
3 years ago by @fordham1
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1The uses and abuses of systematic reviews
E. Fordham, T. Lawrie, K. MacGilchrist, and A. Bryant. OSF Preprints, (October 2021)org / 10. 31219 / osf. io / mp 4 f 2.
3 years ago by @fordham1
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1Ivermectin for the prevention of COVID-19: addressing potential bias and medical fraud
A. Hill, M. Mirchandani, L. Ellis, and V. Pilkington. Journal of Antimicrobial Chemotherapy, (2022)
3 years ago by @fordham1
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1Strictly regular use of ivermectin as prophylaxis for COVID-19 leads to a 90\% reduction in COVID-19 mortality rate, in a dose-response manner: definitive results of a prospective observational study of a strictly controlled 223,128 population from a city-wide program in Southern Brazil.
L. Kerr, F. Baldi, R. Lôbo, W. Assagra, F. Proen, J. Hibberd, J. Chamie-Quintero, P. Kory, and F. Cadegiani. Research Gate, (2022)
3 years ago by @fordham1
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1Early treatment of Covid-19 with repurposed therapies: The TOGETHER adaptive platform trial
G. Reis, and E. Mills. Powerpoint slide deck, (2021)
3 years ago by @fordham1
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