Mitogen-activated protein kinase p38 is a serin/threonine kinase originally isolated from lipopolysaccharide stimulated monocytes. There are 4 isoforms; p38-a activation has been most widely studied for inflammation...
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The anti-inflammatory potential of an oral p38 MAPK inhibitor in humans in vivo suggests that p38 MAPK inhibitors may provide a new therapeutic option in the treatment of inflammatory diseases. Boehringer Ingelheim. 2002 Branger J, et al
HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY. Judith Branger, Bernt van den Blink, Sebastiaan Weijer, Abhya Gupta, Sander J.H. van Deventer, C. Erik Hack, Maikel P. Peppelenbosch, and Tom van der Poll
C. Krasel, M. Bunemann, K. Lorenz, and M. Lohse. J Biol Chem, 280 (10):
9528-35(March 2005)Krasel, Cornelius Bunemann, Moritz Lorenz, Kristina Lohse, Martin
J Research Support, Non-U.S. Gov't United States The Journal of biological
chemistry J Biol Chem. 2005 Mar 11;280(10):9528-35. Epub 2005 Jan
5..
J. Pitcher, M. Lohse, J. Codina, M. Caron, and R. Lefkowitz. Biochemistry, 31 (12):
3193-7(March 1992)Pitcher, J Lohse, M J Codina, J Caron, M G Lefkowitz, R J HL16037/HL/NHLBI
NIH HHS/United States Research Support, U.S. Gov't, P.H.S. United
states Biochemistry Biochemistry. 1992 Mar 31;31(12):3193-7..
S. Merighi, P. Mirandola, D. Milani, K. Varani, S. Gessi, K. Klotz, E. Leung, P. Baraldi, and P. Borea. J Invest Dermatol, 119 (4):
923-33(October 2002)Merighi, Stefania Mirandola, Prisco Milani, Daniela Varani, Katia
Gessi, Stefania Klotz, Karl-Norbert Leung, Edward Baraldi, Pier Giovanni
Borea, Pier Andrea United States The Journal of investigative dermatology
J Invest Dermatol. 2002 Oct;119(4):923-33..
Y. Nakagawa, M. Nagasawa, S. Yamada, A. Hara, H. Mogami, V. Nikolaev, M. Lohse, N. Shigemura, Y. Ninomiya, and I. Kojima. PLoS One, 4 (4):
e5106(2009)Nakagawa, Yuko Nagasawa, Masahiro Yamada, Satoko Hara, Akemi Mogami,
Hideo Nikolaev, Viacheslav O Lohse, Martin J Shigemura, Noriatsu
Ninomiya, Yuzo Kojima, Itaru Research Support, Non-U.S. Gov't United
States PloS one PLoS One. 2009;4(4):e5106. Epub 2009 Apr 8..
A. Ruiz-Gomez, J. Humrich, C. Murga, U. Quitterer, M. Lohse, and J. Mayor. J Biol Chem, 275 (38):
29724-30(September 2000)Ruiz-Gomez, A Humrich, J Murga, C Quitterer, U Lohse, M J Mayor,
F Jr Research Support, Non-U.S. Gov't United states The Journal of
biological chemistry J Biol Chem. 2000 Sep 22;275(38):29724-30..