Mitogen-activated protein kinase p38 is a serin/threonine kinase originally isolated from lipopolysaccharide stimulated monocytes. There are 4 isoforms; p38-a activation has been most widely studied for inflammation...
Dr. Noboru Ashida, Department of Geriatric Medicine, Graduate School of Medicine, Kyoto University, 54 Kawaramachi, Shogoin Sakyo-ku, Kyoto 606-8507, Japan. Voice +81-75-751-3465; fax: +81-75-751-3574; ash@kuhp.kyoto.u.ac.jp.
The anti-inflammatory potential of an oral p38 MAPK inhibitor in humans in vivo suggests that p38 MAPK inhibitors may provide a new therapeutic option in the treatment of inflammatory diseases. Boehringer Ingelheim. 2002 Branger J, et al
HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY. Judith Branger, Bernt van den Blink, Sebastiaan Weijer, Abhya Gupta, Sander J.H. van Deventer, C. Erik Hack, Maikel P. Peppelenbosch, and Tom van der Poll
J. Humrich, C. Bermel, M. Bunemann, L. Harmark, R. Frost, U. Quitterer, and M. Lohse. J Biol Chem, 280 (20):
20042-50(May 2005)Humrich, Jan Bermel, Christina Bunemann, Moritz Harmark, Linda Frost,
Robert Quitterer, Ursula Lohse, Martin J In Vitro United States The
Journal of biological chemistry J Biol Chem. 2005 May 20;280(20):20042-50.
Epub 2005 Mar 2..
C. Krasel, S. Dammeier, R. Winstel, J. Brockmann, H. Mischak, and M. Lohse. J Biol Chem, 276 (3):
1911-5(January 2001)Krasel, C Dammeier, S Winstel, R Brockmann, J Mischak, H Lohse, M
J Research Support, Non-U.S. Gov't United States The Journal of biological
chemistry J Biol Chem. 2001 Jan 19;276(3):1911-5. Epub 2000 Oct 19..
S. Reiner, N. Ziegler, C. Leon, K. Lorenz, K. von Hayn, C. Gachet, M. Lohse, and C. Hoffmann. Mol Pharmacol, 76 (6):
1162-71(December 2009)Reiner, Susanne Ziegler, Nicole Leon, Catherine Lorenz, Kristina
von Hayn, Kathrin Gachet, Christian Lohse, Martin J Hoffmann, Carsten
Research Support, Non-U.S. Gov't United States Molecular pharmacology
Mol Pharmacol. 2009 Dec;76(6):1162-71. Epub 2009 Sep 9..
J. Benovic, J. Onorato, M. Lohse, H. Dohlman, C. Staniszewski, M. Caron, and R. Lefkowitz. Br J Clin Pharmacol, (1990)Benovic, J L Onorato, J Lohse, M J Dohlman, H G Staniszewski, C Caron,
M G Lefkowitz, R J England British journal of clinical pharmacology
Br J Clin Pharmacol. 1990;30 Suppl 1:3S-12S..
S. Graham, P. Combes, M. Crumiere, K. Klotz, and J. Dickenson. Eur J Pharmacol, 420 (1):
19-26(May 2001)Graham, S Combes, P Crumiere, M Klotz, K N Dickenson, J M Research
Support, Non-U.S. Gov't Netherlands European journal of pharmacology
Eur J Pharmacol. 2001 May 18;420(1):19-26..
M. Trincavelli, D. Tuscano, M. Marroni, K. Klotz, A. Lucacchini, and C. Martini. Biochim Biophys Acta, 1591 (1-3):
55-62(August 2002)Trincavelli, M Letizia Tuscano, Daniela Marroni, Matteo Klotz, Karl-Norbert
Lucacchini, Antonio Martini, Claudia Research Support, Non-U.S. Gov't
Netherlands Biochimica et biophysica acta Biochim Biophys Acta. 2002
Aug 19;1591(1-3):55-62..
J. Puurunen, M. Lohse, and U. Schwabe. Naunyn Schmiedebergs Arch Pharmacol, 336 (5):
471-7(November 1987)Puurunen, J Lohse, M J Schwabe, U In Vitro Research Support, Non-U.S.
Gov't Germany, west Naunyn-Schmiedeberg's archives of pharmacology
Naunyn Schmiedebergs Arch Pharmacol. 1987 Nov;336(5):471-7..
J. Humrich, C. Bermel, T. Grubel, U. Quitterer, and M. Lohse. J Biol Chem, 278 (7):
4474-81(February 2003)Humrich, Jan Bermel, Christina Grubel, Tobias Quitterer, Ursula Lohse,
Martin J United States The Journal of biological chemistry J Biol
Chem. 2003 Feb 14;278(7):4474-81. Epub 2002 Dec 3..
K. Lorenz, J. Schmitt, E. Schmitteckert, and M. Lohse. Nat Med, 15 (1):
75-83(January 2009)Lorenz, Kristina Schmitt, Joachim P Schmitteckert, Eva M Lohse, Martin
J Research Support, Non-U.S. Gov't United States Nature medicine
Nat Med. 2009 Jan;15(1):75-83. Epub 2008 Dec 7..
M. Lohse, S. Andexinger, J. Pitcher, S. Trukawinski, J. Codina, J. Faure, M. Caron, and R. Lefkowitz. J Biol Chem, 267 (12):
8558-64(April 1992)Lohse, M J Andexinger, S Pitcher, J Trukawinski, S Codina, J Faure,
J P Caron, M G Lefkowitz, R J DK 19318/DK/NIDDK NIH HHS/United States
HL 16037/HL/NHLBI NIH HHS/United States Research Support, Non-U.S.
Gov't Research Support, U.S. Gov't, P.H.S. United states The Journal
of biological chemistry J Biol Chem. 1992 Apr 25;267(12):8558-64..
R. Winstel, S. Freund, C. Krasel, E. Hoppe, and M. Lohse. Proc Natl Acad Sci U S A, 93 (5):
2105-9(March 1996)Winstel, R Freund, S Krasel, C Hoppe, E Lohse, M J Research Support,
Non-U.S. Gov't United states Proceedings of the National Academy
of Sciences of the United States of America Proc Natl Acad Sci U
S A. 1996 Mar 5;93(5):2105-9..