Mitogen-activated protein kinase p38 is a serin/threonine kinase originally isolated from lipopolysaccharide stimulated monocytes. There are 4 isoforms; p38-a activation has been most widely studied for inflammation...
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The anti-inflammatory potential of an oral p38 MAPK inhibitor in humans in vivo suggests that p38 MAPK inhibitors may provide a new therapeutic option in the treatment of inflammatory diseases. Boehringer Ingelheim. 2002 Branger J, et al
HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY. Judith Branger, Bernt van den Blink, Sebastiaan Weijer, Abhya Gupta, Sander J.H. van Deventer, C. Erik Hack, Maikel P. Peppelenbosch, and Tom van der Poll
E. Adachi, Y. Kazoe, Y. Sato, Y. Suzuki, T. Urano, T. Ueyama, N. Saito, V. Nikolaev, M. Lohse, M. Tominaga and 1 other author(s). Pflugers Arch, 459 (1):
227-34(November 2009)Adachi, Eisuke Kazoe, Yutaka Sato, Yohei Suzuki, Yuko Urano, Tetsumei
Ueyama, Takehiko Saito, Naoaki Nikolaev, Viacheslav O Lohse, Martin
J Tominaga, Makoto Mogami, Hideo Research Support, Non-U.S. Gov't
Germany Pflugers Archiv : European journal of physiology Pflugers
Arch. 2009 Nov;459(1):227-34. Epub 2009 Aug 13..
M. Castro, F. Dicker, J. Vilardaga, C. Krasel, M. Bernhardt, and M. Lohse. Endocrinology, 143 (10):
3854-65(October 2002)Castro, Marian Dicker, Frank Vilardaga, Jean-Pierre Krasel, Cornelius
Bernhardt, Manfred Lohse, Martin J Research Support, Non-U.S. Gov't
United States Endocrinology Endocrinology. 2002 Oct;143(10):3854-65..
J. Benovic, J. Onorato, M. Lohse, H. Dohlman, C. Staniszewski, M. Caron, and R. Lefkowitz. Br J Clin Pharmacol, (1990)Benovic, J L Onorato, J Lohse, M J Dohlman, H G Staniszewski, C Caron,
M G Lefkowitz, R J England British journal of clinical pharmacology
Br J Clin Pharmacol. 1990;30 Suppl 1:3S-12S..
J. Humrich, C. Bermel, M. Bunemann, L. Harmark, R. Frost, U. Quitterer, and M. Lohse. J Biol Chem, 280 (20):
20042-50(May 2005)Humrich, Jan Bermel, Christina Bunemann, Moritz Harmark, Linda Frost,
Robert Quitterer, Ursula Lohse, Martin J In Vitro United States The
Journal of biological chemistry J Biol Chem. 2005 May 20;280(20):20042-50.
Epub 2005 Mar 2..
S. Graham, P. Combes, M. Crumiere, K. Klotz, and J. Dickenson. Eur J Pharmacol, 420 (1):
19-26(May 2001)Graham, S Combes, P Crumiere, M Klotz, K N Dickenson, J M Research
Support, Non-U.S. Gov't Netherlands European journal of pharmacology
Eur J Pharmacol. 2001 May 18;420(1):19-26..
C. Krasel, S. Dammeier, R. Winstel, J. Brockmann, H. Mischak, and M. Lohse. J Biol Chem, 276 (3):
1911-5(January 2001)Krasel, C Dammeier, S Winstel, R Brockmann, J Mischak, H Lohse, M
J Research Support, Non-U.S. Gov't United States The Journal of biological
chemistry J Biol Chem. 2001 Jan 19;276(3):1911-5. Epub 2000 Oct 19..
M. Trincavelli, D. Tuscano, M. Marroni, K. Klotz, A. Lucacchini, and C. Martini. Biochim Biophys Acta, 1591 (1-3):
55-62(August 2002)Trincavelli, M Letizia Tuscano, Daniela Marroni, Matteo Klotz, Karl-Norbert
Lucacchini, Antonio Martini, Claudia Research Support, Non-U.S. Gov't
Netherlands Biochimica et biophysica acta Biochim Biophys Acta. 2002
Aug 19;1591(1-3):55-62..