Ketamine and dextromethorphan are widely abused psychoactive substances. Inhibition of N-methyl-d-aspartate receptors (NMDARs) results in neurobehavioral effects including hallucinations, “out of body” sensations, and dissociative effects. However, little is known about a possible extended addictive class-effect linked to pharmacologically-related amino-adamantane derivatives (e.g. amantadine and memantine). To read the full article, choose “Institutional Login” and search for “Midlands Partnership”.