A population pharmacokinetic model to guide clozapine dose selection, based on age, sex, ethnicity, body weight and smoking status - Reeves - British Journal of Clinical Pharmacology - Wiley Online Library
Guidance on clozapine dosing in treatment-resistant schizophrenia is based largely on data from White young adult males. This study aimed to investigate the pharmacokinetic profiles of clozapine and N-desmethylclozapine (norclozapine) across the age range, accounting for sex, ethnicity, smoking status, and body weight. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.