Polypharmacy, defined as the use of five or more medications, has been repeatedly linked to fall incidence, and recently it was cross‐sectionally associated with gait disturbances. Our objectives were to evaluate cross‐sectional and longitudinal associations between polypharmacy and gait performance in a well‐established clinic‐based cohort study. We also assessed whether gait impairments could mediate associations between number of medications and fall incidence.. To read the full article, log in using your NHS Athens details. To access full-text: click “Log in/Register” (top right hand side). Click ‘Institutional Login’ then select 'OpenAthens Federation', then ‘NHS England’. Enter your Athens details to view the article.