In Benin, two medicinal plants are commonly used by rural populations to treat skin infections. Very few investigations are carried out on them against skin infections, despite their increased use. The present study is carried out on these two anti-infectious plants, namely: Senna alata (L.) Roxb. (Leguminosae-Caesalpinioideae) and Lantana cumara L. (Verbenaceae). The objective of this study is to characterize the groups of chemicals contained in the two herbal drugs. The phytochemical tests carried out on the two (02) plant extracts revealed that the different drugs contain Anthocyanins, Quinone Derivatives, Coumarins, Free Anthracenics, Saponosides, Triterpenes, Mucilages and Reducing Compounds which gave them the antibacterial properties. The best yield is obtained with the aqueous extract.