Accumulating neuroimaging evidence has documented group-level abnormalities in brain structure and function in individuals with severe mental disorders.1 However, the diversity of findings on localization, magnitude, and clinical sensitivity; the lack of robust associations with polygenic risk scores; and poor diagnostic classification using machine learning2 suggest that the discriminatory power of neuroimaging data alone is limited and that the individual brain patterns are highly heterogeneous. Although disappointing from a clinical point of view, this lack of direct translation of group-level findings to the individual is in line with the substantial individual patient heterogeneity in clinical and cognitive profiles.. Please contact the library to request a copy of this article - http://bit.ly/1Xyazai