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Frontostriatal functional connectivity correlates with repetitive behaviour across autism spectrum disorder and obsessive–compulsive disorder - ProQuest


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Psychological Medicine; Cambridge Vol. 49, Iss. 13,  (Oct 2019): 2247-2255. DOI:10.1017/S0033291718003136

Background

Autism spectrum disorder (ASD) and obsessive–compulsive disorder (OCD) are neurodevelopmental disorders with considerable overlap in terms of their defining symptoms of compulsivity/repetitive behaviour. Little is known about the extent to which ASD and OCD have common versus distinct neural correlates of compulsivity. Previous research points to potentially common dysfunction in frontostriatal connectivity, but direct comparisons in one study are lacking. Here, we assessed frontostriatal resting-state functional connectivity in youth with ASD or OCD, and healthy controls. In addition, we applied a cross-disorder approach to examine whether repetitive behaviour across ASD and OCD has common neural substrates.. To read the full article, log in using your MPFT NHS OpenAthens details.

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