The clinical and pathological definitions of vascular-related cognitive impairment and dementia have undergone many changes over the decades, and today still remain nebulous. Until the 1960s, most dementia, particularly in older people, was thought to be secondary to cerebral arteriosclerosis. This view of dementia changed in the second half of last century with the ascendency of the Alzheimer's disease neuropathology paradigm for dementia and the consequent de-emphasis of vascular causes of dementia......To read the full article, log in using your SSSFT NHS OpenAthens details.