The Selecton server enables detecting the selective forces at a single amino-acid site. The ratio of non-synonymous (amino-acid altering) to synonymous (silent) substitutions, known as the Ka/Ks ratio, is used to estimate both positive and purifying selection at each amino-acid site
The Bioinformatics Links Directory features curated links to molecular resources, tools and databases. The links listed in this directory are selected on the basis of recommendations from bioinformatics experts in the field. We also rely on input from our community of bioinformatics users for suggestions.
ProPhylER shows your protein like you have never seen it before: Through the lens of Evolutionary Constraint, inferred from comparative analyses of closely related sequences.